METHODS: Twenty patients with Fitzpatrick grades III-IV facial conditions (skin laxity with melasma, n = 9; post-inflammatory erythema and scars, n = 5; and enlarged pores, n = 6) and treated with MFRS were enrolled. Transepidermal water loss (TEWL, using Ultrascan UC22), skin sensitivity (ten-item Sensitive Scale, SS-10), melanin index (MI), melasma area and severity index (MASI), red areas (VISIA), and thickness and density of the epidermis and dermis on ultrasonography were compared between baseline and 6 months after all treatment sessions.
RESULTS: Twenty patients completed a 6-month follow-up after two MFRS treatments. During days 1-3 post-treatment, the TEWL values gradually increased to the peak and decreased to baseline levels (BD) on day 7. There was no significant difference in TEWL compared with baseline in month (M) 1, M3, and M6. There were no significant changes in the thickness and density of the epidermis. Although the thickness and density of the dermis increased, there was no significant difference compared to baseline. There was no significant difference in the MI, MASI, and SS-10 score before and after MFRS treatment. After treatment with MFRS, the red area and scarring reduced significantly (p < .01), and no significant difference was observed in other patients.
CONCLUSIONS: MFRS is a safe and effective treatment for facial cosmetic conditions. The skin barrier function is not impaired by MFRS treatment, since it does not cause skin sensitivity or melasma exacerbation.
方法:20例FitzpatrickIII-IV级面部疾病患者(皮肤松弛伴黄褐斑,n=9;炎症后红斑和疤痕,n=5;和毛孔增大,n=6)并接受MFRS治疗。经皮水分流失(TEWL,使用UltrascanUC22),皮肤敏感性(十项敏感量表,SS-10),黑色素指数(MI),黄褐斑面积和严重程度指数(MASI),红色区域(VISIA),在基线和所有治疗疗程后6个月之间比较超声检查中表皮和真皮的厚度和密度。
结果:20例患者在两次MFRS治疗后完成了6个月的随访。治疗后第1-3天,TEWL值在第7天逐渐增加至峰值并降低至基线水平(BD)。与基线相比,TEWL在月(M)1,M3和M6中没有显着差异。表皮的厚度和密度没有明显变化。虽然真皮的厚度和密度增加,与基线相比无显著差异.MI无显著差异,MASI,MFRS治疗前后SS-10评分。用MFRS治疗后,红色区域和疤痕显着减少(p<0.01),其他患者无显著差异。
结论:MFRS是一种安全有效的面部美容治疗方法。MFRS治疗不会损害皮肤屏障功能,因为它不会引起皮肤敏感或黄褐斑恶化。