背景:螺内酯(SPL)是女性痤疮的有效治疗方法,但对皮肤生物物理特性的其他影响仍有待研究。
目的:本研究的目的是探讨用于治疗女性痤疮的口服SPL对皮肤生物物理特性的影响,包括水合,经皮水分流失(TEWL),皮肤表面脂质(SSL)水平,机械性能,颜色,pH值,和孔径。
方法:对25名接受口服SPL治疗的泰国痤疮妇女进行随访6个月。皮肤水合,TEWL,SSL级别,机械性能,颜色,pH值,和前额的毛孔大小,胸部,在基线和口服SPL治疗后2,4和6个月时评估和内臂。还评估了面部和上背部孔径。临床结果是与基线相比,每次就诊时这些皮肤生物物理特性的变化。
结果:皮肤水合作用,TEWL,SSL级别,颜色,pH值,和孔径在整个研究中保持稳定。6个月时的面部皮肤参数表现出以下变化:水合水平,7.60(95%置信区间[CI],-59.74至74.94);TEWL,-2.36(95%CI,-5.77至1.06);L*值,0.51(95%CI,-0.70至1.72);个体类型角度,1.65(95%CI-2.27至5.57);pH,0.01(95%CI-0.43至0.46);孔径,-0.24(95%CI,-1.21至0.73);SSL级别,7.60(95%CI-59.74至74.94)。观察到面部机械性能的改善。R0(表示皮肤紧密度)和R1(表示弹性)显示显著降低(-0.076[95%CI,-0.141至-0.010]和-0.016[95%CI,-0.033至-0.001])。R3和R4(代表疲劳效应)也得到改善(-0.091[95%CI,-0.158至-0.025]和-0.022[95%CI,-0.044至-0.001])。躯干和内臂区域的参数保持稳定,除了皮肤弹性和累人的影响,表现出与面部区域相似的改善趋势。这些变化早在4个月就很明显了。
结论:用于痤疮的口服SPL不会损害皮肤屏障。此外,皮肤力学性能在4~6个月时有所改善。
BACKGROUND: Spironolactone (SPL) is an effective treatment for women acne, but other effects on skin biophysical properties remain to be investigated.
OBJECTIVE: The aim of the current study was to explore the effects of oral SPL used to treat women acne on skin biophysical properties, including hydration, transepidermal water loss (TEWL), skin surface lipid (SSL) levels, mechanical properties, color, pH, and pore size.
METHODS: Twenty-five Thai women with acne treated with oral SPL were followed for 6 months. Skin hydration, TEWL, SSL levels, mechanical properties, color, pH, and pore size of the forehead, chest, and inner arm were evaluated at baseline and 2, 4, and 6 months after treatment with oral SPL. Facial and upper back pore size were also assessed. Clinical outcomes were changes in these skin biophysical properties at each visit compared with baseline.
RESULTS: Skin hydration, TEWL, SSL levels, color, pH, and pore size remained stable throughout the study. Facial skin parameters at 6 months demonstrated the following changes: hydration levels, 7.60 (95% confidence interval [CI], -59.74 to 74.94); TEWL, -2.36 (95% CI, -5.77 to 1.06); L* value, 0.51 (95% CI, -0.70 to 1.72); individual typology angle, 1.65 (95% CI -2.27 to 5.57); pH, 0.01 (95% CI -0.43 to 0.46); pore size, -0.24 (95% CI, -1.21 to 0.73); and SSL levels, 7.60 (95% CI -59.74 to 74.94). Improvement of facial mechanical properties was observed. R0 (indicating skin tightness) and R1 (indicating elasticity) showed significant decreases (-0.076 [95% CI, -0.141 to -0.010] and -0.016 [95% CI, -0.033 to -0.001]). R3 and R4 (representing tiring effects) were also improved (-0.091 [95% CI, -0.158 to -0.025] and -0.022 [95% CI, -0.044 to -0.001]). Parameters in the truncal and inner arm areas remained stable, except for skin elasticity and tiring effects, which exhibited a similar trend of improvement as the facial area. The changes were notable as early as 4 months.
CONCLUSIONS: Oral SPL used for acne did not impair the skin barrier. Moreover, the skin mechanical properties were improved at 4 to 6 months.