背景:痤疮的严重程度和治疗反应,黄褐斑,酒渣鼻可能受到目前尚不清楚的各种内部和外部因素的影响。本研究旨在通过实际病例对照研究为上述条件的影响因素提供证据。
方法:实施了一项由60个问题组成的在线调查,收集人口统计信息,社会经济学,遗传因素,生活习惯,环境暴露,和皮肤护理行为。然后,我们构造了单变量和多变量逻辑回归。此外,我们分析了暴露与结局之间的剂量-反应关系.
结果:共有399人,包括94名痤疮患者,107名黄褐斑患者,并纳入91例酒渣鼻患者。痤疮和黄褐斑与屏幕时间呈正相关(痤疮:比值比[OR]:2.24,95%置信区间[CI]:1.25-4.02;黄褐斑:OR:1.59,95%CI:1.09-2.31),而运动对痤疮(OR:0.31,95%CI:0.13-0.77)和黄褐斑(OR:0.42,95%CI:0.22-0.80)均具有剂量反应关系。此外,男性与痤疮风险升高相关(OR:6.62,95%CI:1.01-43.26).年龄(OR:1.15,95%CI:1.07-1.24)和不规则排便(OR:2.99,95%CI:1.11-8.08)是黄褐斑的独立危险因素。酒渣鼻与BMI呈正相关(OR:1.17,95%CI:1.01~1.35)。
结论:在我们的研究中,我们强调运动是痤疮和黄褐斑的独立保护因素,呈剂量-反应趋势.相反,电子设备的长期使用与痤疮和黄褐斑的高风险独立相关.酒渣鼻,然而,更有可能与BMI有关。
BACKGROUND: The severity and treatment response of acne,
melasma, and rosacea may be influenced by various currently unclear internal and external factors. This study aimed to provide evidence to the influencing factors for the mentioned conditions through a real-world case-control study.
METHODS: An online survey consisting of 60 questions was implemented, collecting information on demographics, socioeconomics, genetic factors, lifestyle habits, environmental exposures, and skin care behaviors. Then we constructed univariate and multivariate logistic regressions. Furthermore, we analyzed the dose-response relationship between exposure and outcome.
RESULTS: A total of 399 individuals, including 94 acne patients, 107
melasma patients, and 91 rosacea patients were included. Acne and
melasma were positively correlated with screen time (acne: odds ratio [OR]: 2.24, 95% confidence interval [CI]: 1.25-4.02;
melasma: OR: 1.59, 95% CI: 1.09-2.31), while exercise exerted a protective effect on both acne (OR: 0.31, 95% CI: 0.13-0.77) and melasma (OR: 0.42, 95% CI: 0.22-0.80) in a dose-response relationship. In addition, males were associated with an elevated risk of acne (OR: 6.62, 95% CI: 1.01-43.26). Aging (OR: 1.15, 95% CI: 1.07-1.24) and irregular bowel movements (OR: 2.99, 95% CI: 1.11-8.08) were independent risk factors for
melasma. Rosacea was positively associated with BMI (OR: 1.17, 95% CI: 1.01-1.35).
CONCLUSIONS: In our study, we highlighted exercise as an independent protective factor for both acne and melasma in a dose-response trend. Inversely, extended use of electronic equipment was independently associated with higher risks of acne and melasma. Rosacea, however, was more likely to be related with BMI.