Abstract：
Intermittent theta burst stimulation (iTBS) using 600 pulses is an effective and FDA-cleared transcranial magnetic stimulation (TMS) protocol for major depressive disorder (MDD). Prolonged iTBS (piTBS) using 1,800 pulses could increase the effectiveness of TMS for MDD, but its real-world effectiveness is still debated. We assessed the safety, tolerability, and preliminary effectiveness of a 3x daily piTBS 1,800 pulses protocol delivered over 2 weeks in 27 participants. Only four participants (18.2%) achieved response, two of them achieving remission (9.1%). Five participants (18.5%) experienced tolerability issues. Future studies should focus on the neurophysiological effects of TBS protocols to determine optimal parameters.
摘要：
使用600个脉冲的间歇性theta脉冲刺激（iTBS）是一种有效且FDA批准的经颅磁刺激（TMS）方案，用于重度抑郁症（MDD）。使用1,800个脉冲的延长iTBS（piTBS）可以提高TMS对MDD的有效性，但它在现实世界中的有效性仍然存在争议。我们评估了安全性,耐受性,在27名参与者中，在2周内提供了每日3倍piTBS1,800脉冲方案的初步有效性。只有四名参与者(18.2%)获得回应，其中两人获得缓解(9.1%)。五名参与者(18.5%)经历了耐受性问题。未来的研究应集中在TBS协议的神经生理效应上，以确定最佳参数。
