{Reference Type}: Journal Article
{Title}: Prolonged intermittent theta burst stimulation in the treatment of major depressive disorder: a case series.
{Author}: Richard M;Noiseux C;Desbeaumes Jodoin V;Blumberger DM;Sheen J;Mansouri F;Elkrief L;Longpré-Poirier C;Lespérance P;Miron JP;
{Journal}: Psychiatry Res
{Volume}: 315
{Issue}: 0
{Year}: 09 2022
{Factor}: 11.225
{DOI}: 10.1016/j.psychres.2022.114709
{Abstract}: Intermittent theta burst stimulation (iTBS) using 600 pulses is an effective and FDA-cleared transcranial magnetic stimulation (TMS) protocol for major depressive disorder (MDD). Prolonged iTBS (piTBS) using 1,800 pulses could increase the effectiveness of TMS for MDD, but its real-world effectiveness is still debated. We assessed the safety, tolerability, and preliminary effectiveness of a 3x daily piTBS 1,800 pulses protocol delivered over 2 weeks in 27 participants. Only four participants (18.2%) achieved response, two of them achieving remission (9.1%). Five participants (18.5%) experienced tolerability issues. Future studies should focus on the neurophysiological effects of TBS protocols to determine optimal parameters.