■据推测,重度抑郁症和精神分裂症与癌症密切相关。然而,这些精神疾病与肺癌发展之间的关联仍不确定.本研究旨在探讨重度抑郁障碍之间的因果关系。精神分裂症,和肺癌的风险。
■进行了双样本双向/多变量和中介孟德尔随机化(MR)分析。使用了有关重度抑郁症(N=500,199)和精神分裂症(N=127,906)的全基因组摘要数据。有关肺癌风险的数据(总体而言,腺癌,和鳞状细胞)是从一组欧洲血统的个体中收集的(N=27,209)。三种与吸烟有关的行为(吸烟开始,打包多年的吸烟,和每天吸烟的香烟)包括在多变量和中介MR分析中。
精神分裂症患者患肺癌的风险明显增高(比值比(OR)=1.144,95%置信区间(95%CI):1.048-1.248,P=0.003)。每日吸烟量部分介导精神分裂症与肺癌总体发病风险的关系(OR=1.185,95%CI:1.112~1.264,P=0.021,介导效应比例:61.033%)。然而,没有可靠的证据表明重度抑郁症与肺癌风险之间存在关联(总体而言,腺癌,和鳞状细胞癌)。
■研究结果表明精神分裂症与肺癌风险增加之间存在关联,吸烟是部分中介。当吸烟被纳入回归分析时,精神分裂症诊断的解释力降低,这表明吸烟可能是该人群肺癌的重要原因。鉴于精神分裂症患者的高吸烟率,这些结果强调需要进一步研究以探索吸烟影响的潜在机制。因此,应更加重视监测精神分裂症患者的呼吸健康状况,并实施早期干预措施以解决吸烟相关行为.
UNASSIGNED: Major depressive disorder and schizophrenia have been hypothesized to be closely associated with cancer. However, the associations between these psychiatric conditions and the development of lung cancer remain uncertain. This study aimed to explore the causal relationship among major depressive disorder, schizophrenia, and the risk of lung cancer.
UNASSIGNED: Two-sample bidirectional/multivariable and mediation Mendelian randomization (MR) analyses were conducted. Genome-wide summary data on major depressive disorder (N=500,199) and schizophrenia (N=127,906) were utilized. Data on the risk of lung cancer (overall, adenocarcinoma, and squamous cell) were collected from a cohort of individuals of European ancestry (N=27,209). Three smoking-related behaviors (smoking initiation, pack years of smoking, and cigarettes smoked per day) were included in the multivariable and mediation MR analyses.
UNASSIGNED: Patients with schizophrenia had a significantly greater risk of developing lung cancer (odds ratio (OR) = 1.144, 95% confidence interval (95% CI): 1.048-1.248, P = 0.003). The number of cigarettes smoked per day partially mediated the relationship between schizophrenia and the overall risk of lung cancer (OR = 1.185, 95% CI: 1.112-1.264, P = 0.021, proportion of mediation effect: 61.033%). However, there is no reliable evidence indicating an association between major depressive disorder and the risk of lung cancer (overall, adenocarcinoma, and squamous cell cancer).
UNASSIGNED: The findings indicated an association between schizophrenia and an increased risk of lung cancer, with smoking served as a partial mediator. When smoking was included in the regression analysis, the explanatory power of schizophrenia diagnosis was reduced, suggesting that smoking may be an important causal contributor to lung cancer in this population. Given the high prevalence of smoking among individuals with schizophrenia, these results underscore the need for further research to explore the underlying mechanisms of smoking\'s impact. Consequently, greater emphasis should be placed on monitoring the respiratory health of individuals with schizophrenia and implementing early interventions to address smoking-related behaviors.