Abstract：
Nitric oxide is a key signalling molecule that elicits a range of biological functions to maintain vascular homeostasis. A reduced availability of nitric oxide is implicated in the progression of cardiovascular diseases and increases the risk of pathogenic events.
To compare the concentration of nitric oxide metabolites in healthy adults between winter and summer months.
An observational study of healthy adults (age 32 ± 9 years) living in central Scotland.
Thirty-four healthy adults (13 females) were monitored for 7 days in summer and winter to record sunlight exposure (ultraviolet-A (UV-A) radiation), diet, and physical activity. At the end of each phase, blood pressure was measured, and samples of blood and saliva collected. The samples were analysed to determine the concentrations of plasma and salivary nitrate and nitrite and serum 25-hydroxyvitamin D (25(OH)D).
The participants maintained similar diets in each measurement phase but were exposed to more UV-A radiation (550%) and undertook more moderate-vigorous physical activity (23%) in the summer than in winter. Plasma nitrite (46%) and serum 25(OH)D (59%) were higher and blood pressure was lower in the summer compared to winter months. Plasma nitrite concentration was negatively associated with systolic, diastolic, and mean arterial blood pressure.
Plasma nitrite, an established marker of nitric oxide synthesis, is higher in healthy adults during the summer than in winter. This may be mediated by a greater exposure to UV-A which stimulates the release of nitric oxide metabolites from skin stores. While it is possible that seasonal variation in nitric oxide availability may contribute to an increased blood pressure in the winter months, the overall impact on cardiovascular health remains to be determined.
To compare the concentration of nitric oxide metabolites in healthy adults between winter and summer months.
An observational study of healthy adults (age 32 ± 9 years) living in central Scotland.
Thirty-four healthy adults (13 females) were monitored for 7 days in summer and winter to record sunlight exposure (ultraviolet-A (UV-A) radiation), diet, and physical activity. At the end of each phase, blood pressure was measured, and samples of blood and saliva collected. The samples were analysed to determine the concentrations of plasma and salivary nitrate and nitrite and serum 25-hydroxyvitamin D (25(OH)D).
The participants maintained similar diets in each measurement phase but were exposed to more UV-A radiation (550%) and undertook more moderate-vigorous physical activity (23%) in the summer than in winter. Plasma nitrite (46%) and serum 25(OH)D (59%) were higher and blood pressure was lower in the summer compared to winter months. Plasma nitrite concentration was negatively associated with systolic, diastolic, and mean arterial blood pressure.
Plasma nitrite, an established marker of nitric oxide synthesis, is higher in healthy adults during the summer than in winter. This may be mediated by a greater exposure to UV-A which stimulates the release of nitric oxide metabolites from skin stores. While it is possible that seasonal variation in nitric oxide availability may contribute to an increased blood pressure in the winter months, the overall impact on cardiovascular health remains to be determined.
摘要：
一氧化氮是一种关键的信号分子，可引发一系列生物学功能以维持血管稳态。一氧化氮的可用性降低与心血管疾病的进展有关，并增加了致病事件的风险。
比较冬季和夏季健康成人一氧化氮代谢物的浓度。
对居住在苏格兰中部的健康成年人（年龄32±9岁）的观察性研究。
在夏季和冬季对34名健康成年人（13名女性）进行了7天的监测，以记录阳光照射（紫外线A（UV-A）辐射），饮食，和身体活动。在每个阶段结束时,测量血压，收集血液和唾液样本.分析样品以确定血浆和唾液硝酸盐和亚硝酸盐以及血清25-羟基维生素D(25(OH)D)的浓度。
参与者在每个测量阶段都保持相似的饮食，但夏季比冬季暴露于更多的紫外线-A辐射（550％），并进行了更多的中等强度体力活动（23％）。与冬季相比，夏季的血浆亚硝酸盐（46％）和血清25（OH）D（59％）较高，血压较低。血浆亚硝酸盐浓度与收缩压呈负相关，舒张压,和平均动脉血压。
血浆亚硝酸盐，一氧化氮合成的既定标志，健康成年人在夏季比冬季高。这可以通过对UV-A的更大暴露来介导,所述UV-A刺激一氧化氮代谢物从皮肤储存中的释放。虽然一氧化氮可用性的季节性变化可能会导致冬季血压升高，对心血管健康的总体影响尚待确定.
比较冬季和夏季健康成人一氧化氮代谢物的浓度。
对居住在苏格兰中部的健康成年人（年龄32±9岁）的观察性研究。
在夏季和冬季对34名健康成年人（13名女性）进行了7天的监测，以记录阳光照射（紫外线A（UV-A）辐射），饮食，和身体活动。在每个阶段结束时,测量血压，收集血液和唾液样本.分析样品以确定血浆和唾液硝酸盐和亚硝酸盐以及血清25-羟基维生素D(25(OH)D)的浓度。
参与者在每个测量阶段都保持相似的饮食，但夏季比冬季暴露于更多的紫外线-A辐射（550％），并进行了更多的中等强度体力活动（23％）。与冬季相比，夏季的血浆亚硝酸盐（46％）和血清25（OH）D（59％）较高，血压较低。血浆亚硝酸盐浓度与收缩压呈负相关，舒张压,和平均动脉血压。
血浆亚硝酸盐，一氧化氮合成的既定标志，健康成年人在夏季比冬季高。这可以通过对UV-A的更大暴露来介导,所述UV-A刺激一氧化氮代谢物从皮肤储存中的释放。虽然一氧化氮可用性的季节性变化可能会导致冬季血压升高，对心血管健康的总体影响尚待确定.
