PDF(Pubmed)
Abstract：
Chemotherapy is a critical treatment for endocrine-related cancers; however, chemoresistance and disease recurrence remain a challenge. The interplay between cancer cells and the tumor microenvironment via cell adhesion molecules (CAMs) promotes drug resistance, known as cell adhesion-mediated drug resistance (CAM-DR). CAMs are cell surface molecules that facilitate cell-to-cell or cell-to-extracellular matrix binding. CAMs exert an adhesion effect and trigger intracellular signaling that regulates cancer cell stemness maintenance, survival, proliferation, metastasis, epithelial-mesenchymal transition, and drug resistance. To understand these mechanisms, this review focuses on the role of CD44, cadherins, selectins, and integrins in CAM-DR in endocrine-related cancers.
摘要：
化疗是内分泌相关癌症的关键治疗方法；然而，化疗耐药和疾病复发仍然是一个挑战。癌细胞和肿瘤微环境之间的相互作用通过细胞粘附分子（CAM）促进耐药性，称为细胞粘附介导的耐药性（CAM-DR）。CAM是促进细胞与细胞或细胞与细胞外基质结合的细胞表面分子。CAM发挥粘附作用并触发调节癌细胞干性维持的细胞内信号，生存,扩散,转移,上皮-间质转化，和抗药性。为了理解这些机制，这篇综述集中在CD44，钙黏着蛋白，选择素,内分泌相关癌症中CAM-DR中的整合素。
