{Reference Type}: Journal Article
{Title}: Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook.
{Author}: Ruan Y;Chen L;Xie D;Luo T;Xu Y;Ye T;Chen X;Feng X;Wu X;
{Journal}: Front Endocrinol (Lausanne)
{Volume}: 13
{Issue}: 0
{Year}: 2022
{Factor}: 6.055
{DOI}: 10.3389/fendo.2022.865436
{Abstract}: Chemotherapy is a critical treatment for endocrine-related cancers; however, chemoresistance and disease recurrence remain a challenge. The interplay between cancer cells and the tumor microenvironment via cell adhesion molecules (CAMs) promotes drug resistance, known as cell adhesion-mediated drug resistance (CAM-DR). CAMs are cell surface molecules that facilitate cell-to-cell or cell-to-extracellular matrix binding. CAMs exert an adhesion effect and trigger intracellular signaling that regulates cancer cell stemness maintenance, survival, proliferation, metastasis, epithelial-mesenchymal transition, and drug resistance. To understand these mechanisms, this review focuses on the role of CD44, cadherins, selectins, and integrins in CAM-DR in endocrine-related cancers.