%0 Journal Article
%T Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook.
%A Ruan Y
%A Chen L
%A Xie D
%A Luo T
%A Xu Y
%A Ye T
%A Chen X
%A Feng X
%A Wu X
%J Front Endocrinol (Lausanne)
%V 13
%N 0
%D 2022
%M 35464064
%F 6.055
%R 10.3389/fendo.2022.865436
%X Chemotherapy is a critical treatment for endocrine-related cancers; however, chemoresistance and disease recurrence remain a challenge. The interplay between cancer cells and the tumor microenvironment via cell adhesion molecules (CAMs) promotes drug resistance, known as cell adhesion-mediated drug resistance (CAM-DR). CAMs are cell surface molecules that facilitate cell-to-cell or cell-to-extracellular matrix binding. CAMs exert an adhesion effect and trigger intracellular signaling that regulates cancer cell stemness maintenance, survival, proliferation, metastasis, epithelial-mesenchymal transition, and drug resistance. To understand these mechanisms, this review focuses on the role of CD44, cadherins, selectins, and integrins in CAM-DR in endocrine-related cancers.