RESULTS: 1284 of 3157 stool samples (~40%) from children (≤5 years) with acute gastroenteritis tested positive for one or more enteric viruses with positivity rates 25.11%, 8.74%, 6.62% and 6.11% for GARV, HAdV-F, AstV and NoV respectively. Co-infection was observed in 5.31% of cases. Associated clinical/meteorological variables like age, sex, symptoms, temperature and precipitation were assessed to find any correlation between these and enteric virus infection rates. >70% of viral gastroenteritis cases were observed in 6-24 months\' age group. GARV and AstV infection occurred mostly during cooler months while HAdV-F infection mostly occurred during warmer periods. No definite seasonality was observed for NoV infections. Clinical severity associated with GARV infection was higher compared to other enteric viruses. Genotyping of rotavirus positive samples revealed G3P[8] was the predominantly circulating GARV genotype throughout the study period.
CONCLUSIONS: GARV remained the predominant viral agent of acute gastroenteritis among children though its prevalence rates in this region declined significantly compared to the previous years (2010-2016). The prevalence of other enteric viruses was below 10%.
CONCLUSIONS: This study provides valuable insights regarding the current burden of viral gastroenteritis in Eastern India. The 2-year study in children will provide the baseline data for future surveillance studies in evaluating the impact of the introduced GARV vaccine on the overall prevalence of viral gastroenteritis.
结果:来自急性胃肠炎儿童(≤5岁)的3157个粪便样本中的1284个(〜40%)检测出一种或多种肠道病毒呈阳性,阳性率为25.11%,8.74%,GARV为6.62%和6.11%,HAdV-F,分别为AstV和NoV。5.31%的病例合并感染。相关的临床/气象变量,如年龄,性别,症状,对温度和降水进行了评估,以发现这些与肠道病毒感染率之间的任何相关性。在6-24个月大的人群中观察到>70%的病毒性胃肠炎病例。GARV和AstV感染主要发生在较凉爽的月份,而HAdV-F感染主要发生在较温暖的时期。NoV感染未观察到明确的季节性。与其他肠道病毒相比,与GARV感染相关的临床严重程度更高。轮状病毒阳性样本的基因分型显示G3P[8]是整个研究期间主要的循环GARV基因型。
结论:GARV仍然是儿童急性胃肠炎的主要病毒因子,尽管与前几年(2010-2016年)相比,GARV在该地区的患病率显著下降。其他肠道病毒的流行率低于10%。
结论:这项研究提供了有关印度东部病毒性胃肠炎当前负担的宝贵见解。这项为期2年的儿童研究将为未来的监测研究提供基线数据,以评估引入的GARV疫苗对病毒性胃肠炎总体患病率的影响。