人类腺病毒36(HAdV-36)感染与肥胖有关,低脂水平,以及改善动物模型和人类的血糖水平和胰岛素敏感性,尽管流行病学研究仍存在争议。因此,这项研究调查了青少年HAdV-36血清阳性与血糖控制之间的关系.这项观察性研究检查了460名年轻人(体重正常的246名和肥胖的214名受试者)。所有参与者都接受了人体测量评估,血压,循环空腹血糖水平,脂质,胰岛素,和抗HAdV-36抗体;此外,计算胰岛素抵抗的稳态模型评估(HOMA-IR).总之,57.17%的受试者为HAdV-36血清阳性。此外,与正常体重的受试者相比,肥胖受试者的HAdV-36血清阳性率更高(59%vs.55%)。BMI(33.1vs.32.3kg/m2,p=0.03),和腰围(107vs.104厘米,p=0.02),胰岛素水平(21vs.16.3µU/mL,p=0.003),和HOMA-IR(4.6与与血清阴性受试者相比,HAdV-36阳性肥胖受试者的3.9,p=0.02)更高。在肥胖组中,在校正总胆固醇的模型中,HAdV-36血清阳性与降低血糖水平有关。甘油三酯水平,年龄和性别(β=-10.44,p=0.014)。此外,在肥胖组中,观察到HAdV-36血清阳性与胰岛素水平之间存在统计学显著的正相关.这些发现表明,自然HAdV-36感染可以改善肥胖受试者的血糖控制,但不能改善高胰岛素血症。
Human adenovirus-36 (HAdV-36) infection has been linked to obesity, low lipid levels, and improvements in blood glucose levels and insulin sensitivity in animal models and humans, although epidemiological studies remain controversial. Therefore, this study investigated the relationship between HAdV-36 seropositivity and glycemic control in youths. This observational study examined 460 youths (246 with normal weight and 214 obese subjects). All participants underwent assessments for anthropometry, blood pressure, circulating fasting levels of glucose, lipids, insulin, and anti-HAdV-36 antibodies; additionally, the homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. In all, 57.17% of the subjects were HAdV-36 seropositive. Moreover, HAdV-36 seroprevalence was higher in obese subjects compared to their normal weight counterparts (59% vs. 55%). BMI (33.1 vs. 32.3 kg/m2, p = 0.03), and waist circumference (107 vs. 104 cm, p = 0.02), insulin levels (21 vs. 16.3 µU/mL, p = 0.003), and HOMA-IR (4.6 vs. 3.9, p = 0.02) were higher in HAdV-36-positive subjects with obesity compared to seronegative subjects. In the obese group, HAdV-36 seropositivity was associated with a reducing effect in blood glucose levels in a model adjusted for total cholesterol, triglyceride levels, age and sex (β = -10.44, p = 0.014). Furthermore, a statistically significant positive relationship was observed between HAdV-36 seropositivity and insulin levels in the obesity group. These findings suggest that natural HAdV-36 infection improves glycemic control but does not ameliorate hyperinsulinemia in obese subjects.