Abstract：
Oxaliplatin, widely used as a chemotherapy drug for colorectal cancer, is known to cause various adverse reactions. In particular, special attention for the development of portal hypertension associated with porto-sinusoidal vascular disease is necessary, as it is a serious adverse life-threating reaction, although rare. We herein report a case of oxaliplatin-related portal hypertension that developed several years after oxaliplatin administration and led to esophageal varices and refractory massive ascites. Clinical physicians should be aware of the possibility of oxaliplatin-induced portal hypertension and its possible development over a long period after discontinuation of the drug.
摘要：
奥沙利铂,广泛用作结直肠癌的化疗药物，已知会引起各种不良反应。特别是,需要特别注意与门窦血管疾病相关的门脉高压的发展，因为这是一种严重的有害威胁生命的反应，虽然罕见。我们在此报告一例与奥沙利铂相关的门静脉高压症，该病例在服用奥沙利铂后几年发展，并导致食管静脉曲张和难治性大量腹水。临床医师应意识到奥沙利铂诱导的门静脉高压症的可能性及其在停药后长期发展的可能性。
