{Reference Type}: Case Reports
{Title}: Oxaliplatin-related Portal Hypertension Complicated with Esophageal Varices and Refractory Massive Ascites.
{Author}: Yazaki T;Kawashima K;Ishimura N;Kataoka M;Fukunaga M;Hyakudomi R;Tajima Y;Moriyama I;Araki A;Kadota K;Shibagaki K;Tobita H;Ishihara S;
{Journal}: Intern Med
{Volume}: 61
{Issue}: 21
{Year}: Nov 2022 1
{Factor}: 1.282
{DOI}: 10.2169/internalmedicine.9266-21
{Abstract}: Oxaliplatin, widely used as a chemotherapy drug for colorectal cancer, is known to cause various adverse reactions. In particular, special attention for the development of portal hypertension associated with porto-sinusoidal vascular disease is necessary, as it is a serious adverse life-threating reaction, although rare. We herein report a case of oxaliplatin-related portal hypertension that developed several years after oxaliplatin administration and led to esophageal varices and refractory massive ascites. Clinical physicians should be aware of the possibility of oxaliplatin-induced portal hypertension and its possible development over a long period after discontinuation of the drug.