%0 Case Reports
%T Oxaliplatin-related Portal Hypertension Complicated with Esophageal Varices and Refractory Massive Ascites.
%A Yazaki T
%A Kawashima K
%A Ishimura N
%A Kataoka M
%A Fukunaga M
%A Hyakudomi R
%A Tajima Y
%A Moriyama I
%A Araki A
%A Kadota K
%A Shibagaki K
%A Tobita H
%A Ishihara S
%J Intern Med
%V 61
%N 21
%D Nov 2022 1
%M 35370236
%F 1.282
%R 10.2169/internalmedicine.9266-21
%X Oxaliplatin, widely used as a chemotherapy drug for colorectal cancer, is known to cause various adverse reactions. In particular, special attention for the development of portal hypertension associated with porto-sinusoidal vascular disease is necessary, as it is a serious adverse life-threating reaction, although rare. We herein report a case of oxaliplatin-related portal hypertension that developed several years after oxaliplatin administration and led to esophageal varices and refractory massive ascites. Clinical physicians should be aware of the possibility of oxaliplatin-induced portal hypertension and its possible development over a long period after discontinuation of the drug.