来自食用茶花的天然外泌体样纳米囊泡通过 ROS 生成和微生物群调节抑制转移性乳腺癌。
关键词: AF633, Alexa Fluor 633-labeled phalloidin ALP, alkaline phosphatase ALT, alanine aminotransferase AST, aspartate aminotransferase BUN, urea nitrogen Breast cancer CDK, CYCLIN-dependent kinase CRE, creatinine DAF-FM DA, 4-amino-5-methylamino-2′,7′-difluorofluorescein diacetate DAPI, 4′,6-diamidino-2-phenylindole DCFH-DA, dichloro-dihydro-fluorescein diacetate DGDG, digalactosyl diacylglycerols DHE, dihydroethidium DLS, dynamic light scattering DiO, 3,3′-dioctadecyloxacarbocyanine perchlorate DiR, 1,1′-dioctadecyl-3,3,3′′,3′-tetramethylindotricarbocyanine iodide EC, epicatechin ECG, epicatechin gallate EGCG, epigallocatechin gallate Exosome-like nanoparticle FBS, fetal bovine serum GIT, gastrointestinal tract H&E, Hematoxylin & Eosin HPLC, high-performance liquid chromatography Intravenous injection LC‒MS, liquid chromatography‒mass spectrometry MFI, mean fluorescence intensity MGDG, monogalactosyl diacylglycerols MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Metastasis Microbiota modulation NO, nitrogen monoxide NPs, nanoparticles OUT, operational taxonomic unit Oral administration PA, phosphatidic acids PBS, phosphate-buffered saline PC, phosphatidylcholines PDI, polydispersity index PE, phosphatidylethanolamines PG, phosphatidylglycerol PI, phosphatidylinositol PLT, platelets PMe, phosphatidylmethanol PS, phosphatidylserine RBC, red blood cell RNS, reactive nitrogen species ROS generation ROS, reactive oxygen species SA, superoxide anion SQDG, sulphoquinovosyl diylyceride TEM, transmission electron microscopy TFENs, exosome-like NPs from tea flowers TG, triglyceride TUNEL, TdT-mediated dUTP Nick-end labeling Tea flower WBC, white blood cell AF633, Alexa Fluor 633-labeled phalloidin ALP, alkaline phosphatase ALT, alanine aminotransferase AST, aspartate aminotransferase BUN, urea nitrogen Breast cancer CDK, CYCLIN-dependent kinase CRE, creatinine DAF-FM DA, 4-amino-5-methylamino-2′,7′-difluorofluorescein diacetate DAPI, 4′,6-diamidino-2-phenylindole DCFH-DA, dichloro-dihydro-fluorescein diacetate DGDG, digalactosyl diacylglycerols DHE, dihydroethidium DLS, dynamic light scattering DiO, 3,3′-dioctadecyloxacarbocyanine perchlorate DiR, 1,1′-dioctadecyl-3,3,3′′,3′-tetramethylindotricarbocyanine iodide EC, epicatechin ECG, epicatechin gallate EGCG, epigallocatechin gallate Exosome-like nanoparticle FBS, fetal bovine serum GIT, gastrointestinal tract H&E, Hematoxylin & Eosin HPLC, high-performance liquid chromatography Intravenous injection LC‒MS, liquid chromatography‒mass spectrometry MFI, mean fluorescence intensity MGDG, monogalactosyl diacylglycerols MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Metastasis Microbiota modulation NO, nitrogen monoxide NPs, nanoparticles OUT, operational taxonomic unit Oral administration PA, phosphatidic acids PBS, phosphate-buffered saline PC, phosphatidylcholines PDI, polydispersity index PE, phosphatidylethanolamines PG, phosphatidylglycerol PI, phosphatidylinositol PLT, platelets PMe, phosphatidylmethanol PS, phosphatidylserine RBC, red blood cell RNS, reactive nitrogen species ROS generation ROS, reactive oxygen species SA, superoxide anion SQDG, sulphoquinovosyl diylyceride TEM, transmission electron microscopy TFENs, exosome-like NPs from tea flowers TG, triglyceride TUNEL, TdT-mediated dUTP Nick-end labeling Tea flower WBC, white blood cell
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DOI:10.1016/j.apsb.2021.08.016
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