Abstract：
The nuclear envelope (NE) separates genomic DNA from the cytoplasm in eukaryotes. The structure of the NE is dynamically altered not only in mitotic disassembly and reassembly but also during interphase. Recent studies have shown that the NE is frequently damaged by various cellular stresses that degenerate NE components and/or disrupt their functional interactions. These stresses are referred to as \'NE stress\'. Accumulating evidence has demonstrated that NE stress potentially causes severe cellular dysfunctions, such as cell death and genome instability. In this review, the concept of NE stress, the processes repairing damage of the NE caused by NE stress, and the molecular mechanisms by which NE stress contributes to disease pathogenesis are introduced.
摘要：
核膜（NE）将基因组DNA与真核生物的细胞质分开。NE的结构不仅在有丝分裂的分解和重组中而且在间期中都会动态改变。最近的研究表明，NE经常受到各种细胞应激的破坏，这些应激使NE成分退化和/或破坏其功能相互作用。这些应力称为“NE应力”。越来越多的证据表明，NE应激可能导致严重的细胞功能障碍，如细胞死亡和基因组不稳定。在这次审查中,NE应力的概念，修复由NE应力引起的NE损伤的过程，介绍了NE应激促进疾病发病的分子机制。
