核膜(NE)将基因组DNA与细胞质分开,并为核质运输提供分子平台。高阶染色质组织,细胞核和细胞骨架之间的物理联系。最近的研究表明,NE经常被称为“NE应力”的各种应力破坏,导致严重的细胞功能障碍。越来越多的证据揭示了NE应激在广泛疾病病理中的关键作用。在中枢神经系统(CNS),NE功能障碍损害神经发育,并与几种神经系统疾病有关,如阿尔茨海默病和常染色体显性遗传的脑白质营养不良。在这次审查中,总结了NE的结构和功能,介绍了NE胁迫和NE胁迫响应的概念。此外,描述了NE在CNS发育中的重要作用以及NE应激与神经系统疾病之间的机制联系。
The nuclear envelope (NE) separates genomic DNA from the cytoplasm and provides the molecular platforms for nucleocytoplasmic transport, higher-order chromatin organization, and physical links between the nucleus and cytoskeleton. Recent studies have shown that the NE is often damaged by various stresses termed \"NE stress\", leading to critical cellular dysfunction. Accumulating evidence has revealed the crucial roles of NE stress in the pathology of a broad spectrum of diseases. In the central nervous system (CNS), NE dysfunction impairs neural development and is associated with several neurological disorders, such as Alzheimer\'s disease and autosomal dominant leukodystrophy. In this review, the structure and functions of the NE are summarized, and the concepts of NE stress and NE stress responses are introduced. Additionally, the significant roles of the NE in the development of CNS and the mechanistic connections between NE stress and neurological disorders are described.