Abstract：
Little is known about the epidemiology of systemic vasculitis in South American countries. The aim of this study is to compare the prevalence of systemic vasculitides in two vasculitis referral centers from Brazil and Peru. A cross-sectional study was performed and all patients above 18 years of age, with at least 6 months of follow-up and who met classification or diagnosis criteria for the most common forms of vasculitis, were included. A total of 562 patients with systemic vasculitis were analyzed, 345 (61.4%) from Brazil and 217 (38.6%) from Peru. The frequency of Behçet\'s disease (37.9% vs. 1.8%; p < 0.0001), Takayasu arteritis (TAK) (25.2% vs. 6.9%; p < 0.0001), and giant cell arteritis (9.8% vs. 0.9%; p < 0.0001) was higher in the Brazilian center than the Peruvian one. On the other hand, the frequency of microscopic polyangiitis (MPA) (67.3% vs. 2.8%; p < 0.0001) and renal-limited vasculitis (2.8% vs. 0.0%; p = 0.009) was higher in the Peruvian center. No differences were found concerning other forms of vasculitis. At diagnosis, Brazilian patients with TAK, granulomatosis with polyangiitis, and MPA were younger than Peruvian patients. Epidemiologic differences in the frequency of systemic vasculitis are observed between a vasculitis referral center from Brazil and another from Peru. Key Points • Significant differences are observed regarding the epidemiologic profile of systemic vasculitis between Brazil and Peru. • MPA is the predominant form of vasculitis in Peru while BD and TAK are the most frequent forms of vasculitis in Brazil. • The age at diagnosis of TAK, MPA, and GPA was lower in Brazilian patients than in Peruvian patients.
摘要：
对南美国家系统性血管炎的流行病学知之甚少。这项研究的目的是比较巴西和秘鲁两个血管炎转诊中心的全身血管炎患病率。进行了一项横断面研究，所有18岁以上的患者，至少6个月的随访，谁符合最常见形式的血管炎的分类或诊断标准，包括在内。对562例系统性血管炎患者进行分析,345人（61.4%）来自巴西，217人（38.6%）来自秘鲁。Behçet病的发生频率(37.9%vs.1.8%；p<0.0001)，大动脉炎（TAK）（25.2%vs.6.9%；p<0.0001)，和巨细胞动脉炎(9.8%vs.0.9%；p<0.0001）巴西中部高于秘鲁中部。另一方面,显微镜下多血管炎(MPA)的发生率(67.3%vs.2.8%；p<0.0001）和肾限制性血管炎（2.8%vs.0.0％；p=0.009）在秘鲁中心较高。关于其他形式的血管炎没有发现差异。诊断时,巴西TAK患者，肉芽肿性多血管炎，MPA比秘鲁患者年轻。在巴西的血管炎转诊中心和秘鲁的血管炎转诊中心之间，观察到系统性血管炎发生频率的流行病学差异。要点•观察到巴西和秘鲁之间系统性血管炎的流行病学特征存在显著差异。•MPA是秘鲁血管炎的主要形式，而BD和TAK是巴西最常见的血管炎形式。•TAK的诊断年龄，MPA,巴西患者的GPA低于秘鲁患者。
