代谢组学分析揭示了人肝癌衍生的 HuH - 7 细胞中香叶基香叶酸治疗后溶血磷脂的快速增加。
关键词: ATRA, all-trans retinoic acid Cell death D-MEM, Dulbecco’s modified Eagle’s medium ENPP2, ectonucleotide pyrophosphatase/phosphodiesterase 2 FBS, fetal bovine serum GGA, geranylgeranoic acid GSDMD, gasdermin D Geranylgeranoic acid HMDB, Human Metabolome Database Hepatoma KEGG, Kyoto Encyclopedia of Genes and Genomes LCAT, lecithin cholesterol acyltransferase LIPC, lipase C LPA, lysophosphatidic acid LPC, lysophosphatidylcholine LPCAT, LPC acyltransferase LPE, lysophosphatidylethanolamine LPL, lysophospholipid Lysophospholipids Metabolomics OPLS-DA, orthogonal partial least squares-discriminant analysis PCA, principal component analysis PLA2, phospholipase A2 Q-Tof/MS, quadrupole time-of-flight type mass spectrometry SPH, second primary hepatoma TLR4, toll-like receptor-4 UPLC, ultra-performance liquid chromatography UPRER, unfolded protein response or endoplasmic reticulum stress response VIP, variable importance in the projection
来 源:
DOI:10.1016/j.bbrep.2021.101176
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