PDF(Pubmed)
Abstract：
The invertebrate model, Galleria mellonella, has been widely used to study host-pathogen interactions due to its cheapness, ease of handling, and similar mammalian innate immune system. G. mellonella larvae have been proven to be useful and a reliable model for analyzing pathogenesis mechanisms of multidrug resistant Acinetobacter baumannii, an opportunistic pathogen difficult to kill. This review describes the detailed experimental design of G. mellonella/A. baumannii models, and provides a comprehensive comparison of various virulence factors and therapy strategies using the G. mellonella host. These investigations highlight the importance of this host-pathogen model for in vivo pathogen virulence studies. On the long term, further development of the G. mellonella/A. baumannii model will offer promising insights for clinical treatments of A. baumannii infection.
摘要：
无脊椎动物模型，梅洛内拉广场，由于其廉价，已被广泛用于研究宿主-病原体相互作用，易于处理，和哺乳动物的先天免疫系统相似。G.mellonella幼虫已被证明是分析多药耐药鲍曼不动杆菌发病机制的有用和可靠的模型，一种难以杀死的机会病原体。这篇综述描述了G.mellonella/A的详细实验设计。鲍曼不动模型,并提供了使用G.mellonella宿主的各种毒力因子和治疗策略的综合比较。这些研究强调了这种宿主-病原体模型对于体内病原体毒力研究的重要性。从长远来看，G.mellonella/A的进一步发展鲍曼不动杆菌模型将为鲍曼不动杆菌感染的临床治疗提供有希望的见解。
