{Reference Type}: Journal Article
{Title}: Galleria mellonella as a Good Model to Study Acinetobacter baumannii Pathogenesis.
{Author}: Tao Y;Duma L;Rossez Y;
{Journal}: Pathogens
{Volume}: 10
{Issue}: 11
{Year}: Nov 2021 14
{Factor}: 4.531
{DOI}: 10.3390/pathogens10111483
{Abstract}: The invertebrate model, Galleria mellonella, has been widely used to study host-pathogen interactions due to its cheapness, ease of handling, and similar mammalian innate immune system. G. mellonella larvae have been proven to be useful and a reliable model for analyzing pathogenesis mechanisms of multidrug resistant Acinetobacter baumannii, an opportunistic pathogen difficult to kill. This review describes the detailed experimental design of G. mellonella/A. baumannii models, and provides a comprehensive comparison of various virulence factors and therapy strategies using the G. mellonella host. These investigations highlight the importance of this host-pathogen model for in vivo pathogen virulence studies. On the long term, further development of the G. mellonella/A. baumannii model will offer promising insights for clinical treatments of A. baumannii infection.