关键词： AMA, anti-mitochondrial antibodies ANA, antinuclear antibodies ANCA, antineutrophil cytoplasmic antibodies ASMA, anti-smooth muscle antibodies Anti-CCP, anti-cyclic citrullinated peptide antibodies Anti-GBM, anti-glomerular basement membrane antibodies Autoimmune diseases Autoimmunity BP, bullous pemphigoid Dsg, desmoglein Epitope spreading FITC, fluorescein isothiocyanate HLA, Human Leucocyte Antigen HRP, horseradish peroxidase IgG, immunoglobulin G MHC, major histocompatibility complex Multiple autoimmunity PBS, phosphate buffered saline SSP, sequence specific priming TMB, tetramethylbenzidine/H2O2 Thyroiditis Vitiligo

来  源：   DOI：10.1016/j.jtauto.2021.100132   PDF(Pubmed)

Abstract：
We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.
摘要：
我们报告临床，血清学,和一组与HLA-DRB1*04-DQB1*03:02和HLA-DRB1*03-DQB1*0201单倍型相关的自身免疫性甲状腺炎和白癜风患者的免疫遗传学研究。患者具有可检测的抗甲状腺和抗黑素细胞自身抗体。对MHCII分子与单个患者中显示的各种自身免疫性疾病的临床表现相关的作用进行了严格的审查，这里报道的双胞胎患者也是如此。
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