%0 Journal Article
%T Multiple autoimmunity and epitope spreading in monozygotic twins.
%A Avalos-Díaz E
%A Pérez-Pérez E
%A Granados J
%A Pacheco-Tovar D
%A Bollain-Y-Goytia-de-la-Rosa JJ
%A Herrera-Esparza R
%J J Transl Autoimmun
%V 4
%N 0
%D 2021
%M 34816112
暂无%R 10.1016/j.jtauto.2021.100132
%X We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.