{Reference Type}: Journal Article
{Title}: Multiple autoimmunity and epitope spreading in monozygotic twins.
{Author}: Avalos-Díaz E;Pérez-Pérez E;Granados J;Pacheco-Tovar D;Bollain-Y-Goytia-de-la-Rosa JJ;Herrera-Esparza R;
{Journal}: J Transl Autoimmun
{Volume}: 4
{Issue}: 0
{Year}: 2021
暂无{DOI}: 10.1016/j.jtauto.2021.100132
{Abstract}: We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.