急性乙型病毒性肝炎的定量系统药理学模型
关键词: AHB, acute hepatitis B ALT, alanine aminotransferase CHB, chronic hepatitis B CTL*, activated CTL CTL, antigen-specific cytotoxic T lymphocytes CTLm, memory CTL DC*, activated dendritic cells DC, dendritic cells HB, Hepatitis B HBV, hepatitis B virus, HBV DNA, circulating DNA levels of HBV HBsAg, hepatitis B surface antigen Hep, hepatocytes Hepatitis B Heptot, total hepatocytes IFN, interferon Immune system dynamics LN, lymph node LPC, long-lived plasma cells LV, liver MDSC, myeloid-derived suppressor cells Mechanistic modeling NK*, activated NK NK, natural killer cells ODE, ordinary differential equations PB, plasmablasts PC, plasma cells PL, plasma QSP, quantitative systems pharmacology Quantitative systems pharmacology SPC, short-lived plasma cells TRAIL, tumor necrosis factor–related apoptosis-inducing ligand Th0, naïve T cells Treg, regulatory T cells Viral dynamics anti-HBc, specific antibodies against core hepatitis B antigen anti-HBs, specific antibodies against surface hepatitis B antigen dHep, debris hepatocytes iHep, infected hepatocytes pDC, plasmacytoid DC
来 源:
DOI:10.1016/j.csbj.2021.08.052
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