■移植后淋巴增殖性疾病(PTLD)是肝移植后的罕见并发症。最常见的亚型是B细胞PTLD,通常与EB病毒(EBV)感染有关。T细胞PTLD很少见,与EBV的联系也很少见。
■我们的病人,一个21岁的年轻成年人,呈现给我们的是全身性淋巴结病,肝移植后5年。淋巴结活检提示未另作说明的外周T细胞淋巴瘤,与EBV感染有关。正电子发射断层扫描和计算机断层扫描(PET-CT)扫描显示3期疾病。他接受了标准环磷酰胺治疗,阿霉素,依托泊苷,长春新碱,和泼尼松龙化疗,目前正在缓解。
■未另作说明的外周T细胞淋巴瘤是PTLD的一种罕见亚型,其与EBV的关联更加罕见。少数患者可以通过标准化疗达到完全缓解。
UNASSIGNED: Posttransplant lymphoproliferative disorder (PTLD) is a rare complication seen in the period after liver transplant. The commonest subtype is B-cell PTLD which is usually associated with Epstein-Barr virus (EBV) infection. T-cell PTLD is rare and the association with EBV is again rarer.
UNASSIGNED: Our patient, a 21-year-old young adult, presented to us with generalized lymphadenopathy, 5 years after liver transplantation. The biopsy of the lymph node was suggestive of peripheral T-cell lymphoma not otherwise specified, which was associated with EBV infection. The Positron emission tomography and computerised tomography (PET-CT) scan showed stage 3 disease. He was treated with standard cyclophosphamide, doxorubicin, etoposide, vincristine, and prednisolone chemotherapy and is currently in remission.
UNASSIGNED: Peripheral T-cell lymphoma not otherwise specified is a rare subtype of PTLD and its association with EBV is even more rare. A few patients can achieve complete remission with standard chemotherapy.