与 Aicardi - Gouti è res 综合征和 Singleton - Merten 综合征相关的 MDA5 变体的结构动力学的计算见解。
关键词: Aicardi–Goutières syndrome IFIH1 Singleton–Merten syndrome melanoma differentiation-associated protein 5 molecular dynamic simulation
Mesh : Aortic Diseases / genetics Autoimmune Diseases of the Nervous System / genetics Computational Biology Dental Enamel Hypoplasia / genetics Humans Hydrogen Bonding Interferon-Induced Helicase, IFIH1 / genetics physiology Metacarpus / abnormalities Molecular Conformation Molecular Dynamics Simulation Muscular Diseases / genetics Mutant Proteins / genetics Mutation Mutation, Missense Nervous System Malformations / genetics Odontodysplasia / genetics Osteoporosis / genetics Phenotype Principal Component Analysis RNA / metabolism Thermodynamics Vascular Calcification / genetics
来 源:
DOI:10.3390/biom11081251
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