■这项随机对照试验旨在比较氟化银二胺(SDF)和酪蛋白磷酸肽-无定形氟化钙清漆(CPP-ACPFV)预防龋齿发展的功效,搪瓷击穿,儿童磨牙切牙入矿不足(MIH)对磨牙的敏感性。
■共有100名年龄在6至9岁之间的儿童参加了这项研究,其中两个对侧恒磨牙受到MIH的轻度影响。受影响的磨牙被随机均等地分配接受SDF或CPP-ACPFV治疗。在四个不同的时间点应用干预措施(基线,3、6、9个月),龋齿的发生率,龋齿进展,搪瓷击穿,和敏感性进行了评估。
■这项研究的结果揭示了用SDF和CPP-ACPFV治疗的组之间龋齿发生率的显着差异(P值<0.05)。同样,两组患者龋齿进展差异有统计学意义(P<0.05)。然而,治疗组之间的牙釉质分解评分没有显着差异,因为两组中的大多数牙齿都表现出0分。此外,在整个研究期间,治疗组之间的敏感度无显著差异.
■总而言之,这项研究的结果提供了证据,与CPP-ACPFV治疗的磨牙相比,SDF治疗的磨牙显示出较低的龋齿发生率和较高的龋齿阻滞率.两种干预措施都显示出防止牙釉质破裂和提高敏感性的希望。这些发现强调了SDF和CPP-ACPFV作为龋齿预防和管理的有效治疗方法的潜力。强调早期干预和适当的牙科护理策略在维护口腔健康中的重要性。
■ISRCTN54243749(2022年1月13日)。
UNASSIGNED: This randomized controlled trial aimed to compare the efficacy of silver diamine fluoride (SDF) and Casein Phosphopeptide-Amorphous Calcium Phosphate fluoride Varnish (CPP-ACPFV) in preventing caries development, enamel breakdown, and sensitivity on molars affected by molar incisor hypomineralization (MIH) in children.
UNASSIGNED: A total of 100 children aged 6 to 9 years were enrolled in the study with two contralateral permanent molars mildly affected by MIH. Affected molars were randomly and equally assigned to receive either SDF or CPP-ACPFV treatment. The interventions were applied at four different time points (baseline, 3, 6, 9 months), and the incidence of caries, caries progression, enamel breakdown, and sensitivity were assessed.
UNASSIGNED: The findings of this study revealed significant differences in the incidence of caries between the groups treated with SDF and CPP-ACPFV ( P-value < 0.05). Similarly, there was a significant difference in caries progression between the two groups ( P-value < 0.05). However, no significant differences were observed in enamel breakdown scores between the treatment groups, as the majority of teeth in both groups exhibited a score of 0. Furthermore, there were no significant differences in sensitivity between the treatment groups throughout the study period.
UNASSIGNED: In conclusion, the results of this study provide evidence that molars treated with SDF demonstrated a lower incidence of caries and a higher rate of caries arrest compared to those treated with CPP-ACPFV. Both interventions showed promise in preventing enamel breakdown and improving sensitivity. These findings highlight the potential of SDF and CPP-ACPFV as effective treatments for caries prevention and management, emphasizing the importance of early intervention and appropriate dental care strategies in maintaining oral health.
UNASSIGNED: ISRCTN54243749 (13/01/2022).