纳米药物治疗缺血性卒中的最新进展。
关键词: AEPO, asialo-erythropoietin APOE, apolipoprotein E BBB, blood‒brain barrier BCECs, brain capillary endothelial cells Blood‒brain barrier CAT, catalase COX-1, cyclooxygenase-1 CXCR-4, C-X-C chemokine receptor type 4 Ce-NPs, ceria nanoparticles CsA, cyclosporine A DAMPs, damage-associated molecular patterns GFs, growth factors GPIIb/IIIa, glycoprotein IIb/IIIa HMGB1, high mobility group protein B1 Hb, hemoglobin ICAM-1, intercellular adhesion molecule-1 IL-1β, interleukin-1β IL-6, interleukin-6 Ischemic cascade LFA-1, lymphocyte function-associated antigen-1 LHb, liposomal Hb MCAO, middle cerebral artery occlusion MMPs, matrix metalloproteinases MSC, mesenchymal stem cell NF-κB, nuclear factor-κB NGF, nerve growth factor NMDAR, N-methyl-d-aspartate receptor NOS, nitric oxide synthase NPs, nanoparticles NSCs, neural stem cells Nanomedicine Neuroprotectant PBCA, poly-butylcyanoacrylate PCMS, poly (chloromethylstyrene) PEG, poly-ethylene-glycol PEG-PLA, poly (ethylene-glycol)-b-poly (lactide) PLGA NPs, poly (l-lactide-co-glycolide) nanoparticles PSD-95, postsynaptic density protein-95 PSGL-1, P-selectin glycoprotein ligand-1 RBCs, red blood cells RES, reticuloendothelial system RGD, Arg-Gly-Asp ROS, reactive oxygen species Reperfusion SDF-1, stromal cell-derived factor-1 SHp, stroke homing peptide SOD, superoxide dismutase SUR1-TRPM4, sulfonylurea receptor 1-transient receptor potential melastatin-4 Stroke TEMPO, 2,2,6,6-tetramethylpiperidine-1-oxyl TIA, transient ischemic attack TNF-α, tumor necrosis factor-α Thrombolytics cRGD, cyclic Arg-Gly-Asp e-PAM-R, arginine-poly-amidoamine ester iNOS, inducible nitric oxide synthase miRNAs, microRNAs nNOS, neuron nitric oxide synthase siRNA, small interfering RNA
来 源:
DOI:10.1016/j.apsb.2020.11.019
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