红细胞(红细胞,红细胞)是血液中最丰富的循环细胞,由于其生物相容性特征,已广泛用于药物递送系统(DDS),生物降解性,循环半衰期长。因此,由红细胞膜组成的“伪装”使纳米颗粒成为一个平台,将天然红细胞膜的优点与纳米材料的优点结合在一起。在注射到动物模型的血液中之后,包覆的纳米颗粒模仿红细胞并与周围环境相互作用以实现长期循环。在这次审查中,从各个方面描述了红细胞膜涂层纳米核的仿生平台,特别关注涂层机制,制备方法,验证方法,以及最新的抗肿瘤应用。最后,红细胞膜的进一步功能修饰和尝试融合多个细胞膜的表面特性进行了讨论,为促进多功能纳米仿生系统的广泛研究提供了基础。
Erythrocytes (red blood cells, RBCs) are the most abundant circulating cells in the blood and have been widely used in drug delivery systems (DDS) because of their features of biocompatibility, biodegradability, and long circulating half-life. Accordingly, a \"camouflage\" comprised of erythrocyte membranes renders nanoparticles as a platform that combines the advantages of native erythrocyte membranes with those of nanomaterials. Following injection into the blood of animal models, the coated nanoparticles imitate RBCs and interact with the surroundings to achieve long-term circulation. In this review, the biomimetic platform of erythrocyte membrane-coated nano-cores is described with regard to various aspects, with particular focus placed on the coating mechanism, preparation methods, verification methods, and the latest anti-tumor applications. Finally, further functional modifications of the erythrocyte membranes and attempts to fuse the surface properties of multiple cell membranes are discussed, providing a foundation to stimulate extensive research into multifunctional nano-biomimetic systems.