关键词： AD, Alzheimer's disease ALS, amyotrophic lateral sclerosis AMPK, 5′-adenosine monophosphate-activated protein kinase ATF6, activating transcription factor 6 ATG, autophagy related genes Autophagy BCL-2, B-cell lymphoma 2 BNIP3L, BCL2/adenovirus COPII, coat protein complex II Cerebral ischemia ER, endoplasmic reticulum FOXO, forkhead box O FUNDC1, FUN14 domain containing 1 GPCR, G-protein coupled receptor HD, Huntington's disease IPC, ischemic preconditioning IRE1, inositol-requiring enzyme 1 JNK, c-Jun N-terminal kinase LAMP, lysosomal-associated membrane protein LC3, light chain 3 LKB1, liver kinase B1 Lysosomal activation Mitochondria Mitophagy Natural compounds Neurological disorders Neuroprotection OGD/R, oxygen and glucose deprivation-reperfusion PD, Parkinson's disease PERK, protein kinase R (PKR)-like endoplasmic reticulum kinase PI3K, phosphatidylinositol 3-kinase ROS, reactive oxygen species SQSTM1, sequestosome 1 TFEB, transcription factor EB TIGAR, TP53-induced glycolysis and apoptosis regulator ULK, Unc-51- like kinase Uro-A, urolithin A eIF2a, eukaryotic translation-initiation factor 2 mTOR, mechanistic target of rapamycin ΔΨm, mitochondrial membrane potential

来  源：   DOI：10.1016/j.apsb.2020.10.018   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
Stroke is considered a leading cause of mortality and neurological disability, which puts a huge burden on individuals and the community. To date, effective therapy for stroke has been limited by its complex pathological mechanisms. Autophagy refers to an intracellular degrading process with the involvement of lysosomes. Autophagy plays a critical role in maintaining the homeostasis and survival of cells by eliminating damaged or non-essential cellular constituents. Increasing evidence support that autophagy protects neuronal cells from ischemic injury. However, under certain circumstances, autophagy activation induces cell death and aggravates ischemic brain injury. Diverse naturally derived compounds have been found to modulate autophagy and exert neuroprotection against stroke. In the present work, we have reviewed recent advances in naturally derived compounds that regulate autophagy and discussed their potential application in stroke treatment.
摘要：
中风被认为是死亡和神经残疾的主要原因，这给个人和社区带来了巨大的负担。迄今为止,中风的有效治疗方法受到其复杂病理机制的限制。自噬是指溶酶体参与的细胞内降解过程。自噬通过消除受损或非必需的细胞成分在维持细胞的稳态和存活中起关键作用。越来越多的证据支持自噬保护神经元细胞免受缺血性损伤。然而,在某些情况下,自噬激活诱导细胞死亡并加重缺血性脑损伤。已经发现多种天然衍生的化合物调节自噬并发挥针对中风的神经保护作用。在目前的工作中,我们综述了调节自噬的天然化合物的最新进展,并讨论了它们在卒中治疗中的潜在应用.
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