Abstract:
Caloric restriction (CR)-mediated organ protection has been shown to be extremely efficient in rodent models of acute kidney injury (AKI). Limited understanding of the underlying mechanisms paired with a risk of malnourishment and feasibility problems has hindered the translation of this immense potential to the patient setting. In this mini-review, the current mechanistic concepts of CR-mediated stress-resistance as potential key targets for renal protection in AKI will be highlighted.
摘要:
热量限制(CR)介导的器官保护在急性肾损伤(AKI)的啮齿动物模型中非常有效。对营养不良风险和可行性问题的潜在机制的有限理解阻碍了这种巨大潜力对患者环境的转化。在这个小型审查中,将重点介绍当前CR介导的应激抗性作为AKI肾脏保护的潜在关键靶标的机制概念.