%0 Journal Article
%T Mechanisms of Caloric Restriction-Mediated Stress-Resistance in Acute Kidney Injury.
%A Koehler FC
%A Späth MR
%A Hoyer-Allo KJR
%A Müller RU
%J Nephron
%V 0
%N 0
%D Aug 2021 2
%M 34340234
%F 3.457
%R 10.1159/000517733
%X Caloric restriction (CR)-mediated organ protection has been shown to be extremely efficient in rodent models of acute kidney injury (AKI). Limited understanding of the underlying mechanisms paired with a risk of malnourishment and feasibility problems has hindered the translation of this immense potential to the patient setting. In this mini-review, the current mechanistic concepts of CR-mediated stress-resistance as potential key targets for renal protection in AKI will be highlighted.