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Abstract：
The present article reviews and compares the immunomodulatory activities of Crocus sativus (C. sativus) and Nigella sativa (N. sativa) and their main bioactive compounds. Immunomodulatory effects of these plants, especially with respect to Th1 and Th2 cytokines, are discussed based on relevant articles, books, and conference papers published in English until the end of April 2020, that were retrieved from Web of Science, PubMed, Scopus and Google Scholar databases. C. sativus and its constituents increase immunoglobulin (Ig-)G, interleukin 2 (IL)-2, interferon gamma (IFN-γ), and IFN-γ/IL-4 ratio, but decreased IgM, IL-10 and IL-4 secretion. N. sativa extract and thymoquinone reduce the levels of IL-2, -4, -10, and -12, while enhance IFN-γ and serum IgG1 and 2a. The reviewed articles indicate that C. sativus and N. sativa and their constituents could be potentially considered promising treatments for disorders associated with immune-dysregulation such as asthma and cancer.
摘要：
本文回顾并比较了藏红花的免疫调节活性（C.sativus)和Nigellasativa(N.sativa）及其主要生物活性化合物。这些植物的免疫调节作用，特别是关于Th1和Th2细胞因子，根据相关文章进行讨论，书籍,以及在2020年4月底之前以英语发表的会议论文，这些论文是从WebofScience检索的，PubMed,Scopus和GoogleScholar数据库。C.sativus及其成分增加免疫球蛋白（Ig-）G，白细胞介素2（IL）-2，干扰素γ（IFN-γ），和IFN-γ/IL-4比值，但IgM减少,IL-10和IL-4分泌。紫花苜蓿提取物和百里香醌降低IL-2、-4、-10和-12的水平,同时增强IFN-γ和血清IgG1和2a。综述的文章表明，C.sativus和N.sativa及其成分可能被认为是与免疫失调相关的疾病的有希望的治疗方法，例如哮喘和癌症。
