PDF(Pubmed)
Abstract：
Across the globe, the outbreak of the COVID-19 pandemic is causing distress with governments doing everything in their power to contain the spread of the novel coronavirus (SARS-CoV-2) to prevent morbidity and mortality. Actions are being implemented to keep health care systems from being overstretched and to curb the outbreak. Any policy responses aimed at slowing down the spread of the virus and mitigating its immediate effects on health care systems require a firm basis of information about the absolute number of currently infected people, growth rates, and locations/hotspots of infections. The only way to obtain this base of information is by conducting numerous tests in a targeted way. Currently, in Ghana, there is a centralized testing approach, that takes 4-5 days for samples to be shipped and tested at central reference laboratories with results communicated to the district, regional and national stakeholders. This delay in diagnosis increases the risk of ongoing transmission in communities and vulnerable institutions. We have validated, evaluated and deployed an innovative diagnostic tool on a mobile laboratory platform to accelerate the COVID-19 testing. A preliminary result of 74 samples from COVID-19 suspected cases has a positivity rate of 12% with a turn-around time of fewer than 3 hours from sample taking to reporting of results, significantly reducing the waiting time from days to hours, enabling expedient response by the health system for contact tracing to reduce transmission and additionally improving case management.
UNASSIGNED: Test kits were provided by AngloGold Ashanti Obuasi Mine (AngloGold Ashanti Health Foundation). The American Leprosy Mission donated the PCR machine, and the mobile laboratory van was funded by the Embassy of the Kingdom of the Netherlands (EKN). AAS, YAA was supported by (PANDORA-ID-NET RIA2016E-1609) and ROP supported by EDCTP Senior Fellowship (TMA2016SF), both funded by the European and Developing Countries Clinical Trials Partnership (EDCTP2) programme which is supported under Horizon 2020, the European Union.
UNASSIGNED: Test kits were provided by AngloGold Ashanti Obuasi Mine (AngloGold Ashanti Health Foundation). The American Leprosy Mission donated the PCR machine, and the mobile laboratory van was funded by the Embassy of the Kingdom of the Netherlands (EKN). AAS, YAA was supported by (PANDORA-ID-NET RIA2016E-1609) and ROP supported by EDCTP Senior Fellowship (TMA2016SF), both funded by the European and Developing Countries Clinical Trials Partnership (EDCTP2) programme which is supported under Horizon 2020, the European Union.
摘要：
在全球范围内,COVID-19大流行的爆发正在给各国政府造成困扰，各国政府竭尽全力控制新型冠状病毒(SARS-CoV-2)的传播，以防止发病率和死亡率。正在采取行动，以防止医疗保健系统过度紧张并遏制疫情。任何旨在减缓病毒传播和减轻其对医疗保健系统的直接影响的政策反应都需要关于目前受感染人数绝对数量的坚实基础信息，增长率，以及感染的地点/热点。获得这种信息库的唯一方法是有针对性地进行大量测试。目前,在加纳,有一个集中的测试方法，需要4-5天的时间才能将样品运送到中央参考实验室进行测试，并将结果传达给该地区，区域和国家利益相关者。这种诊断延迟增加了社区和脆弱机构持续传播的风险。我们已经验证了，在移动实验室平台上评估并部署了创新的诊断工具，以加速COVID-19测试。对COVID-19疑似病例的74份样本的初步结果，阳性率为12%，从取样到报告结果的周转时间不到3小时，将等待时间从几天缩短到几小时，使卫生系统能够对接触者追踪做出权宜之计，以减少传播，并进一步改善病例管理。
■测试套件由AngloGoldAshantiObuasi矿山（AngloGoldAshantiHealthFoundation）提供。美国麻风研究团捐赠了PCR仪,和流动实验室面包车由荷兰王国大使馆（EKN）资助。AAS,YAA由（PANDORA-ID-NETRIA2016E-1609）支持，ROP由EDCTP高级研究员（TMA2016SF）支持，两者均由欧洲和发展中国家临床试验伙伴关系（EDCTP2）计划资助，该计划由欧盟Horizon2020支持。
■测试套件由AngloGoldAshantiObuasi矿山（AngloGoldAshantiHealthFoundation）提供。美国麻风研究团捐赠了PCR仪,和流动实验室面包车由荷兰王国大使馆（EKN）资助。AAS,YAA由（PANDORA-ID-NETRIA2016E-1609）支持，ROP由EDCTP高级研究员（TMA2016SF）支持，两者均由欧洲和发展中国家临床试验伙伴关系（EDCTP2）计划资助，该计划由欧盟Horizon2020支持。
