A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the literature.

• 影响指数: 3.838
• 发表时间: 06 2021
• 来源期刊: Pediatr Blood Cancer
• DOI: 10.1002/pbc.29000
• PMID: 33818876
• 文章类型: Case Reports
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Keenan C,Ramirez N,Elijovich L,Klimo P,Bag AK,Acharya S,Upadhyaya SA

关键词: arteriovenous fistula; choriocarcinoma syndrome; metastatic intracranial germ cell tumor; serum beta-hCG

Mesh: Brain Neoplasms / drug therapy pathology; Child; Choriocarcinoma / drug therapy pathology; Female; Hemorrhage / pathology; Humans; Ischemic Stroke / pathology; Lung Neoplasms / drug therapy secondary; Neoplasms, Germ Cell and Embryonal / drug therapy pathology; Uterine Neoplasms / drug therapy pathology

Abstract

Choriocarcinoma syndrome is an uncommon, potentially fatal complication of germ cell tumors (GCTs) in adults, but it is not well documented in children. Pediatric central nervous system (CNS) GCTs comprise a rare group of malignancies not usually associated with extra-CNS metastatic disease. Here, we report the case of a pediatric patient with a suprasellar mixed GCT and pulmonary metastases who presented with intratumoral hemorrhage and stroke. Choriocarcinoma syndrome developed soon after initiating chemotherapy. The primary tumor and pulmonary metastases were successfully treated using a multidisciplinary approach, including neurovascular intervention, chemotherapy, and craniospinal irradiation.