%0 Case Reports
%T A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the literature.
%A Keenan C
%A Ramirez N
%A Elijovich L
%A Klimo P
%A Bag AK
%A Acharya S
%A Upadhyaya SA
%J Pediatr Blood Cancer
%V 68
%N 6
%D 06 2021
%M 33818876
%F 3.838
%R 10.1002/pbc.29000
%X Choriocarcinoma syndrome is an uncommon, potentially fatal complication of germ cell tumors (GCTs) in adults, but it is not well documented in children. Pediatric central nervous system (CNS) GCTs comprise a rare group of malignancies not usually associated with extra-CNS metastatic disease. Here, we report the case of a pediatric patient with a suprasellar mixed GCT and pulmonary metastases who presented with intratumoral hemorrhage and stroke. Choriocarcinoma syndrome developed soon after initiating chemotherapy. The primary tumor and pulmonary metastases were successfully treated using a multidisciplinary approach, including neurovascular intervention, chemotherapy, and craniospinal irradiation.