{Reference Type}: Case Reports
{Title}: A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the literature.
{Author}: Keenan C;Ramirez N;Elijovich L;Klimo P;Bag AK;Acharya S;Upadhyaya SA;
{Journal}: Pediatr Blood Cancer
{Volume}: 68
{Issue}: 6
{Year}: 06 2021
{Factor}: 3.838
{DOI}: 10.1002/pbc.29000
{Abstract}: Choriocarcinoma syndrome is an uncommon, potentially fatal complication of germ cell tumors (GCTs) in adults, but it is not well documented in children. Pediatric central nervous system (CNS) GCTs comprise a rare group of malignancies not usually associated with extra-CNS metastatic disease. Here, we report the case of a pediatric patient with a suprasellar mixed GCT and pulmonary metastases who presented with intratumoral hemorrhage and stroke. Choriocarcinoma syndrome developed soon after initiating chemotherapy. The primary tumor and pulmonary metastases were successfully treated using a multidisciplinary approach, including neurovascular intervention, chemotherapy, and craniospinal irradiation.