arteriovenous fistula

动静脉瘘
  • 文章类型: Journal Article
    目的:比较药物涂层球囊(DCB)与普通球囊血管成形术(PTA)后透析动静脉瘘(AVF)的主要通畅率和再狭窄率。
    方法:这项回顾性研究纳入了157例患者,这些患者在2012年1月至2022年期间接受了AVF血管成形术以治疗固有AVF狭窄。瘘管是头臂(75%),Brachobasillic(17%),和头颅(8%)。指标干预是DCB或经皮腔内血管成形术(PTA),随后进行随访。中心静脉狭窄患者,血栓性瘘,瘘管支架,排除索引程序后的AV移植物或手术干预。
    结果:28例患者使用DCB和129例患者使用PTA进行了动静脉瘘血管成形术。共有108例患者出现单一狭窄,42有2个狭窄,和7个有3个狭窄。这些狭窄的位置在静脉流出道(57%),吻合段(31%),和头弓(12%)。PTA再干预的中位时间为216天,而DCB为304天(p=0.079)。在6个月时,PTA和DCB分别为60.4%和75%(p=0.141)结论:尽管与PTA相比,DCB血管成形术治疗初治功能失调的AVF倾向于改善干预时间和6个月的原发性通畅。这一差异没有达到统计学意义.
    OBJECTIVE: To compare the primary patency and restenosis rates in treatment naieve dialysis arteriovenous fistulas (AVFs) after drug-coated balloons (DCB) versus plain balloon angioplasty (PTA).
    METHODS: This retrospective study included 157 patients who underwent AVF angioplasty for treatment-native AVF stenosis between January 2012 to 2022. The fistulas were Brachiocephalic (75%), Brachiobasilic (17%), and radiocephalic (8%). The index intervention was with either DCB or percutaneous transluminal angioplasty (PTA) with subsequent follow up. Patients with central venous stenosis, thrombosed fistula, fistula stents, AV graft or surgical intervention after the index procedure were excluded.
    RESULTS: Arteriovenous fistula angioplasty was done in 28 patients using DCB and in 129 patients using PTA. A total of 108 patients presented with a single stenosis, 42 with 2 stenoses, and 7 with 3 stenoses. The location of these stenoses was in the venous outflow (57%), the juxta anastomotic segment (31%), and cephalic arch (12%). The median time to re-intervention for the PTA was 216 days compared to 304 days for the DCB (p=0.079). Primary patency at 6 months was 60.4% for PTA and 75% for DCB (p=0.141) CONCLUSION: Although DCB angioplasty of treatmentnaïve dysfunctional AVF tends to improve the time to intervention and 6-month primary patency compared to PTA, this difference did not reach statistical significance.
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  • 文章类型: Case Reports
    背景:肺动静脉瘘(PAVF)是一种罕见的疾病,其症状缺乏特异性。对于冠心病(CHD)患者,高血压和其他常见的心血管疾病,PAVF很容易被忽略。我们介绍了1例大面积PAVF并发冠状动脉粥样硬化性心脏病的介入治疗,以提高对这种复杂疾病的认识。
    方法:一名77岁女性患者因胸闷和活动后呼吸急促入院,在其他医院诊断为冠心病和低氧血症。冠状动脉造影显示患者冠状动脉严重狭窄,而肺血管DSA显示患者患有PAVF。冠状动脉和PAVF介入治疗后,患者的症状明显改善。
    结论:我们介绍了一例经介入治疗的大面积PAVF并发CHD的病例。对于无法解释的低氧血症和与冠心病症状相似的患者,PAVF的可能性往往导致监督,应改进各种辅助检查,避免漏诊。并进行干预治疗,尽可能改善患者预后。
    BACKGROUND: Pulmonary arteriovenous fistula (PAVF) is a rare disease, and its symptoms lack specificity. For patients with coronary heart disease(CHD), hypertension and other common cardiovascular diseases, PAVF is easy to be ignored. We presented a case of massive PAVF complicated with coronary atherosclerotic heart disease by interventional treatment to improve the understanding of this complex disease.
    METHODS: A 77-year-old female patient was admitted to the hospital due to chest tightness and shortness of breath following activities, which was diagnosed with CHD and hypoxemia in other hospitals. Coronary angiography showed that the patient had severe stenosis of coronary artery while pulmonary vascular DSA showing the patient had PAVF. After interventional therapy of both coronary artery and PAVF, the patient\'s symptoms were significantly improved.
    CONCLUSIONS: We presented a case of massive PAVF complicated with CHD by interventional treatment. For patients with unexplained hypoxemia and symptoms similar with CHD, the possibility of PAVF often leads to oversight, and various auxiliary examinations should be improved to avoid missed diagnosis. And intervention treatment should be carried out to improve the prognosis of patients as much as possible.
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  • 文章类型: Journal Article
    背景和目的:为了验证知识的尺度,态度,肾脏血液透析患者动静脉瘘的自我护理实践。方法:通过方法学研究,根据内容验证了有效性的证据,响应过程,和尺度的内部结构。六位评委对内容进行了评估,对6名患者的反应过程进行了验证。在评价内部结构时,将该量表应用于220例患者进行探索性因素分析,并评估McDonald的omega调整和计算指标。结果:量表解释了知识的方差和McDonald的omega值分别为40.4%/0.896、60.7%/0.843和36.9%/0.702(19项),态度(4项),和实践(8项),分别。结论:经过对内容证据的分析,态度量表是有效的。响应过程,和内部结构。动静脉瘘自我护理知识和实践量表解释了不到50%的构造。因此,建议进行新的研究以验证瘘管自理知识和实践的量表.
    Background and Purpose: To validate the scales of knowledge, attitude, and practice of self-care for arteriovenous fistulas in renal patients on hemodialysis. Methods: A methodological study verified the evidence of validity based on the content, response processes, and internal structure of the scales. The content was evaluated by six judges, and the response processes were verified with six patients. In the evaluation of the internal structure, the scales were applied to 220 patients for exploratory factor analysis with evaluation of McDonald\'s omega adjustment and calculation indexes. Results: The scales explained variance and McDonald\'s omega values of 40.4%/0.896, 60.7%/0.843, and 36.9%/0.702 for the knowledge (19 items), attitude (4 items), and practice (8 items), respectively. Conclusions: The scale of attitude was valid after the analysis of the content evidence, response processes, and internal structure. The arteriovenous fistula self-care knowledge and practice scales explained less than 50% of the constructs. Therefore, it is recommended that new studies be conducted to validate scales of knowledge and practice of fistula self-care.
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  • 文章类型: English Abstract
    We have launched a pilot study, called DIADIDEAL, to propose nurse-assistance at home for arterio-venous fistula (AVF) cannulation in home hemodialysis (HHD) patients. The aim of the present study was to describe enrollment of the patients and their nurses.
    All prevalent HD patients on 30th November 2018 with no medical contraindication to HDD treatment and all incident patients on dialysis from the 30th November 2018 to the 21st April 2023 were eligible.
    Among 155 prevalent HD patients, 4 patients were included. Among the 276 incident patients on dialysis during the study period, 6 were included. We have phoned 23 nurse centers during the recruitment period. Eight of them agreed to learn in our unit how to cannulate AVF; 27 private nurses were enrolled.
    The results of the DIADIDEAL study will be available in 2024; we hope it will lead to a reimbursement of nurse-AVF cannulation at home in HDD.
    L’étude DIADIDEAL est une étude pilote sur la ponction de fistule artério-veineuse (FAV) assistée par infirmier libéral en hémodialyse à domicile (HDD). L’objectif de l’étude actuelle est de rapporter le recrutement des patients et de leurs infirmiers diplômés d’État libéraux (IDEL).
    Tous les patients prévalents en HD au 30 novembre 2018 n’ayant pas de contre-indication médicale à un traitement par HDD ainsi que tous les patients incidents en dialyse du 30 novembre 2018 au 21 avril 2023 étaient éligibles.
    Parmi les 155 patients prévalents en hémodialyse, 4 ont été inclus. Parmi les 276 patients incidents en dialyse sur la période, 6 ont été inclus dans l’étude. Parmi les 23 cabinets IDEL contactés pour l’étude, 8 ont accepté et 27 IDEL ont été formés à la ponction de FAV.
    Les résultats de l’étude DIADIDEAL seront disponibles en 2024 et viseront à obtenir une nomenclature pour l’acte de ponction de FAV par les IDEL.
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  • 文章类型: Case Reports
    腹主动脉瘤破裂和髂总动脉瘤(CIA)很少与动静脉瘘(AVF)相关。在这种情况下,手术通常极其困难,预后通常较差。我们报告了一名58岁的男性患者中出现左下肢严重水肿症状的病例,该患者伴有髂总AVF。我们使用动脉瘤壁补片修复瘘管并成功重建髂总静脉,和用于腹主动脉和髂动脉置换的分叉假体移植。
    Ruptured abdominal aortic aneurysms and common iliac artery aneurysms (CIAAs) are rarely associated with an arteriovenous fistula (AVF). In such cases, surgery is frequently extremely difficult and the prognosis is usually poor. We report a case of a ruptured CIAA with a common iliac AVF in a 58-year-old male patient who presented with symptoms of severe edema in his left lower extremity. We used an aneurysm wall patch to repair the fistula and successfully reconstruct the common iliac vein, and a bifurcated prosthetic graft for abdominal aortic and iliac artery replacement.
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  • 文章类型: Journal Article
    目的:血液透析通路诱导的远端缺血(HAIDI)是已知的血液透析(HD)通路并发症。远端血运重建和间隔结扎(DRIL)是许多外科医生首选的HAIDI治疗方法。动脉流入近端(PAI)是一种有前途的替代技术,与钻井不同,保留天然动脉流入。这项研究的目的是报告我们对一系列64例患者的PAI经验。
    方法:这是一个单中心,2017年至2023年接受HAIDIPAI治疗的房室瘘和移植物患者的回顾性队列研究.在大多数情况下,使用4x7锥形聚四氟乙烯(PTFE)移植物将HD入口入流连接到腋窝动脉。该研究的主要结果是HAIDI的解决(完整,局部,或无决议)。次要结果包括功能通畅(原发性和继发性)和PAI后30天并发症。
    结果:在2017年5月至2023年8月期间确定患有PAI的71例患者中,有7例失去随访。总的来说,包括64例患者,平均年龄为65岁(SD15),59.4%(38/64)女性,和37.5%(24/64)非洲裔美国人。研究人群在许多合并症方面值得注意,包括95.3%(61/64)HTN,50%(32/64)CAD,79.7%(51/64)糖尿病,43.8%(28/64)吸烟史。在PAI对HAIDI进行干预之后,55/64(85.9%)患者的缺血症状完全缓解,5/64(7.8%)患者部分消退,2/64(3.1%)患者没有解决,和2/64(3.1%)患者的分辨率未知.在1、12和24个月的主要通畅率为94%,81%,71%,分别。1个月、12个月和24个月时的二次通畅率为97%,87%,84%,分别。30天并发症发生率为10.9%(7/64),5/64(7.8%)血栓形成,1/64(1.6%)血栓形成和感染,1/64(1.6%)继发于中心静脉狭窄的上肢肿胀(通过中心静脉系统血管成形术解决)。12个月和24个月的血栓形成失败率分别为14%(9/64)和15.6%(10/64),分别。
    结论:我们的研究,迄今为止最大的PAI病例系列,证明PAI是HAIDI干预的可靠选择,其安全性和有效性结果与DRIL相当.此外,PAI具有维持天然动脉途径的额外益处。有必要对PAI进行进一步调查,以作为HAIDI管理的DRIL的有希望的替代方案。
    OBJECTIVE: Hemodialysis access-induced distal ischemia (HAIDI) is a known complication of hemodialysis (HD) access. Distal revascularization and interval ligation (DRIL) is the preferred treatment for HAIDI by many surgeons. Proximalization of arterial inflow (PAI) is a promising alternative technique that, unlike DRIL, preserves the native arterial inflow. The purpose of this study is to report our experience with PAI on a series of 64 patients.
    METHODS: This is a single-center, retrospective cohort study of patients with both arteriovenous (AV) fistulas and grafts who underwent PAI for HAIDI from 2017 to 2023. A 4 × 7 tapered polytetrafluoroethylene (PTFE) graft was used to connect HD access inflow to the axillary artery in the majority of cases. The primary outcome of the study is resolution of HAIDI (complete, partial, or no resolution). Secondary outcomes include functional patency (primary and secondary) and 30-day complications following PAI.
    RESULTS: Of the 71 patients identified to have had PAI between May 2017 to August 2023, seven were lost to follow-up. In total, 64 patients were included, with an average age of 65 years (standard deviation, 15 years), 59.4% (38/64) female, and 37.5% (24/64) African American. The study population was notable for numerous comorbid conditions including 95.3% (61/64) hypertension; 50% (32/64) coronary artery disease; 79.7% (51/64) diabetes; and 43.8% (28/64) smoking history. Following PAI intervention for HAIDI, 55 of 64 patients (85.9%) experienced complete resolution of ischemic symptoms; five of 64 patients (7.8%) had partial resolution; two of 64 patients (3.1%) had no resolution, and two of 64 patients (3.1%) had unknown resolution. Primary patency at 1, 12, and 24 months was 94%, 81%, and 71%, respectively. Secondary patency at 1, 12, and 24 months was 97%, 87%, and 84%, respectively. The 30-day complication rate was 10.9% (7/64), with five of 64 (7.8%) thromboses, one of 64 (1.6%) thrombosis and infection, and one of 64 (1.6%) upper extremity swelling secondary to central venous stenosis (resolved with angioplasty of central venous system). Failure rate due to thrombosis at 12 and 24 months was 14% (9/64) and 15.6% (10/64), respectively.
    CONCLUSIONS: Our study, the largest case series of PAI to date, demonstrates that PAI is a reliable option for HAIDI intervention and has comparable safety and efficacy results to DRIL. Furthermore, PAI has the added benefit of maintaining the native arterial pathway. Further investigation of PAI is warranted as a promising alternative to DRIL for HAIDI management.
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  • 文章类型: Case Reports
    背景:肺动静脉畸形(PAVM),也被称为肺动静脉瘘,是一种罕见的血管发育异常。大多数PAVM病例与遗传性出血性毛细血管扩张症(HHT)有关。与PAVM相关的血胸甚至更罕见,有关这一并发症的管理仍然面临挑战。
    方法:我院收治一名突然出现呼吸困难和胸痛的55岁男性患者。他有鼻出血病史,腹膜内生殖细胞肿瘤和PAVM。胸部未增强CT显示左侧胸腔积液伴部分被动肺不张,间隔6天逐渐增加。诊断性胸腔穿刺术进一步显示出血性积液。CT血管造影(CTA)显示左下肺动脉和PAVM的管腔弯曲扩张,并形成动脉瘤。由于他的家人拒绝手术,患者接受了经导管栓塞治疗.然而,左胸腔积液没有明显减少,即使在介入治疗后血红蛋白值也缓慢下降,表明持续活动性出血的可能性。最终,患者接受了左下叶肺叶切除术,结果令人满意。
    结论:PAVM破裂进入胸膜腔引起的大量血胸可导致致命的结果。CTA可以准确诊断这种病理状况。经导管栓塞术常用于治疗PAVM,但在血胸患者中达到理想的效果可能是具有挑战性的。结合我们的案例和文献回顾,当PAVM并发血胸和大直径的引流静脉时,直接根治性手术可以导致成功的结果。
    BACKGROUND: Pulmonary arteriovenous malformation (PAVM), also known as pulmonary arteriovenous fistula, is a rare vascular developmental anomaly. Most cases of PAVM are associated with hereditary hemorrhagic telangiectasia (HHT). Hemothorax associated with PAVM is even rarer, and management concerning this complication still challenges.
    METHODS: A 55-year-old man with sudden onset of dyspnea and chest pain was admitted to our hospital. He had a medical history of epistaxis, intraperitoneal germ cell tumor and PAVM. Chest unenhanced CT revealed the left-sided pleural effusion together with partial passive atelectasis and gradual increase at the interval of six days. Diagnostic thoracocentesis further revealed hemorrhagic effusion. CT angiography (CTA) showed tortuously dilated lumen of the left lower pulmonary artery and PAVM with the formation of aneurysm. Due to his family\'s refusal of surgery, the patient underwent transcatheter embolization therapy. However, the left pleural effusion did not significantly reduce and there was a slow drop in hemoglobin value even after interventional treatment, indicating the possibility of ongoing active bleeding. Eventually, the patient received lobectomy of the left lower lobe with a satisfactory outcome.
    CONCLUSIONS: Massive hemothorax resulting from PAVM rupture into the pleural space can lead to fatal outcomes. CTA can accurately diagnose this pathologic condition. Transcatheter embolization is frequently used in the treatment of PAVM, but it may be challenging to achieve the desirable effect in patients with hemothorax. Combined with our case and literature review, direct radical surgery can lead to a successful outcome when PAVM complicated with hemothorax and a large diameter of the draining vein.
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  • 文章类型: English Abstract
    We have launched a pilot study, called DIADIDEAL, to propose nurse-assistance at home for arterio-venous fistula (AVF) cannulation in home hemodialysis (HHD) patients. The aim of the present study was to describe enrollment of the patients and their nurses.
    All prevalent HD patients on 30th November 2018 with no medical contraindication to HDD treatment and all incident patients on dialysis from the 30th November 2018 to the 21st April 2023 were eligible.
    Among 155 prevalent HD patients, 4 patients were included. Among the 276 incident patients on dialysis during the study period, 6 were included. We have phoned 23 nurse centers during the recruitment period. Eight of them agreed to learn in our unit how to cannulate AVF; 27 private nurses were enrolled.
    The results of the DIADIDEAL study will be available in 2024; we hope it will lead to a reimbursement of nurse-AVF cannulation at home in HDD.
    L’étude DIADIDEAL est une étude pilote sur la ponction de fistule artério-veineuse (FAV) assistée par infirmier libéral en hémodialyse à domicile (HDD). L’objectif de l’étude actuelle est de rapporter le recrutement des patients et de leurs infirmiers diplômés d’État libéraux (IDEL).
    Tous les patients prévalents en HD au 30 novembre 2018 n’ayant pas de contre-indication médicale à un traitement par HDD ainsi que tous les patients incidents en dialyse du 30 novembre 2018 au 21 avril 2023 étaient éligibles.
    Parmi les 155 patients prévalents en hémodialyse, 4 ont été inclus. Parmi les 276 patients incidents en dialyse sur la période, 6 ont été inclus dans l’étude. Parmi les 23 cabinets IDEL contactés pour l’étude, 8 ont accepté et 27 IDEL ont été formés à la ponction de FAV.
    Les résultats de l’étude DIADIDEAL seront disponibles en 2024 et viseront à obtenir une nomenclature pour l’acte de ponction de FAV par les IDEL.
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  • 文章类型: Case Reports
    经皮肾脏手术,尽管侵入性比其他手术小得多,有几个并发症,这可能发生在治疗过程中的任何时间,从最小的肾造口术的性能开始。我们提出了一种极其罕见的经皮肾造口术血管并发症,以动静脉瘘为代表,该患者发生在一名24岁的患者中,该患者已知患有右输尿管肾盂连接部梗阻,没有双J导管渗透性和II-III级肾积水,紧急安装了最小经皮肾造口术。动静脉瘘通过超选择性动脉栓塞解决。
    Percutaneous renal surgery, although much less invasive than other procedures, is subject to several complications, which can occur at any time during the course of treatment, starting from the performance of the minimal nephrostomy procedure. We present an extremely rare vascular complication of percutaneous nephrostomy represented by arteriovenous fistula that occurred in a 24-year-old patient known to have right ureteropelvic junction obstruction operated with the absence of double-J catheter permeability and grade II-III hydronephrosis for which minimal percutaneous nephrostomy was urgently fitted. The arteriovenous fistula was resolved by supraselective artery embolization.
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  • 文章类型: Case Reports
    肺动静脉畸形(PAVM)是导致肺动脉和静脉之间异常连接的血管异常。在80%的案例中,PAVM从出生就存在,但临床表现在儿童时期很少见。这些先天性畸形通常与遗传性出血性毛细血管扩张症(HHT)有关,一种罕见的疾病,影响5000/8000人中的1人。HHT疾病通常由参与TGF-β途径的基因突变引起。然而,大约15%的患者没有基因诊断,在基因诊断中,超过33%的人不符合库拉索岛的标准。这使得儿科年龄组的临床诊断更具挑战性。这里,我们介绍了1例8岁患者,其携带由一种未知突变引起的多重弥漫性PAVM的严重表型,该突变在肺移植结束.表型,正在研究的病例遵循类似HHT的分子模式。因此,已在从外植肺分离的原代内皮细胞(EC)中进行了分子生物学和细胞功能分析。该发现揭示了肺内皮组织的功能丧失和内皮-间质转化的刺激。了解这种转变的分子基础可能为延迟严重病例的肺移植提供新的治疗策略。
    Pulmonary arteriovenous malformations (PAVMs) are vascular anomalies resulting in abnormal connections between pulmonary arteries and veins. In 80% of cases, PAVMs are present from birth, but clinical manifestations are rarely seen in childhood. These congenital malformations are typically associated with Hereditary Hemorrhagic Telangiectasia (HHT), a rare disease that affects 1 in 5000/8000 individuals. HHT disease is frequently caused by mutations in genes involved in the TGF-β pathway. However, approximately 15% of patients do not have a genetic diagnosis and, among the genetically diagnosed, more than 33% do not meet the Curaçao criteria. This makes clinical diagnosis even more challenging in the pediatric age group. Here, we introduce an 8-year-old patient bearing a severe phenotype of multiple diffuse PAVMs caused by an unknown mutation which ended in lung transplantation. Phenotypically, the case under study follows a molecular pattern which is HHT-like. Therefore, molecular- biological and cellular-functional analyses have been performed in primary endothelial cells (ECs) isolated from the explanted lung. The findings revealed a loss of functionality in lung endothelial tissue and a stimulation of endothelial-to-mesenchymal transition. Understanding the molecular basis of this transition could potentially offer new therapeutic strategies to delay lung transplantation in severe cases.
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