PDF(Pubmed)
Abstract：
Human diet comprises several classes of phytochemicals some of which are potentially active against human pathogenic viruses. This study examined available evidence that identifies existing food plants or constituents of edible foods that have been reported to inhibit viral pathogenesis of the human respiratory tract. SCOPUS and PUBMED databases were searched with keywords designed to retrieve articles that investigated the effect of plant-derived food grade substances (PDFGS) on the activities of human pathogenic viruses. Eligible studies for this review were those done on viruses that infect the human respiratory tract. Forty six (46) studies met the specified inclusion criteria from the initial 5,734 hits. The selected studies investigated the effects of different PDFGS on the infectivity, proliferation and cytotoxicity of different respiratory viruses including influenza A virus (IAV), influenza B virus (IBV), Respiratory syncytial virus (RSV), human parainfluenza virus (hPIV), Human coronavirus NL63 (HCoV-NL63), and rhinovirus (RV) in cell lines and mouse models. This review reveals that PDFGS inhibits different stages of the pathological pathways of respiratory viruses including cell entry, replication, viral release and viral-induced dysregulation of cellular homeostasis and functions. These alterations eventually lead to the reduction of virus titer, viral-induced cellular damages and improved survival of host cells. Major food constituents active against respiratory viruses include flavonoids, phenolic acids, tannins, lectins, vitamin D, curcumin, and plant glycosides such as glycyrrhizin, acteoside, geniposide, and iridoid glycosides. Herbal teas such as guava tea, green and black tea, adlay tea, cistanche tea, kuding tea, licorice extracts, and edible bird nest extracts were also effective against respiratory viruses in vitro. The authors of this review recommend an increased consumption of foods rich in these PDFGS including legumes, fruits (e.g berries, citrus), tea, fatty fish and curcumin amongst human populations with high prevalence of respiratory viral infections in order to prevent, manage and/or reduce the severity of respiratory virus infections.
摘要：
人类饮食包含几类植物化学物质,其中一些具有针对人类致病病毒的潜在活性。这项研究检查了现有的证据，这些证据鉴定了现有的食用植物或可食用食品的成分，据报道这些植物或成分抑制了人类呼吸道的病毒发病机理。搜索了SCOPUS和PUBMED数据库，其中包含旨在检索文章的关键字，这些文章研究了植物来源的食品级物质（PDFGS）对人类病原病毒活性的影响。本综述的合格研究是对感染人类呼吸道的病毒进行的研究。从最初的5,734次点击开始，46项研究符合指定的纳入标准。选定的研究调查了不同PDFGS对传染性的影响，包括甲型流感病毒（IAV）在内的不同呼吸道病毒的增殖和细胞毒性，乙型流感病毒（IBV），呼吸道合胞病毒(RSV),人副流感病毒（hPIV），人类冠状病毒NL63（HCoV-NL63），细胞系和小鼠模型中的鼻病毒（RV）。这篇综述揭示了PDFGS抑制呼吸道病毒病理途径的不同阶段，包括细胞进入，复制,病毒释放和病毒诱导的细胞稳态和功能失调。这些改变最终导致病毒滴度降低,病毒诱导的细胞损伤和提高宿主细胞的存活率。对呼吸道病毒具有活性的主要食物成分包括类黄酮，酚酸，单宁,凝集素,维生素D,姜黄素,和植物糖苷如甘草甜素，acteoside,栀子苷,和环烯醚萜苷.草药茶，如番石榴茶，绿茶和红茶，adlay茶，肉豆蔻茶,苦丁茶,甘草提取物,食用燕窝提取物在体外对呼吸道病毒也有效。这篇综述的作者建议增加食用富含这些PDFGS的食物，包括豆类，水果（e.g浆果，柑橘)，茶，在呼吸道病毒感染患病率高的人群中，脂肪鱼和姜黄素可以预防，控制和/或降低呼吸道病毒感染的严重程度。
