已知多种人类呼吸道病毒可能导致急性呼吸道感染(ARIs)。如甲型和乙型流感病毒(HIFV),呼吸道合胞病毒(HRSV),冠状病毒(HCoV),副流感病毒(HPIV),偏肺病毒(HMPV),鼻病毒(HRV),腺病毒(HAdV),博卡病毒(HBoV),和其他人。严重急性呼吸道综合症冠状病毒2(SARS-CoV-2)引起了冠状病毒病(COVID),导致2019年大流行,并对ARIs的循环产生重大影响。这项研究的目的是分析新西伯利亚医院接受ARIs住院的儿童和青少年中常见呼吸道病毒流行模式的变化,俄罗斯,从2019年11月到2022年4月。在2019年和2022年期间,共从3190名0-17岁的住院患者中抽取鼻和喉拭子进行HIFV检测,HRSV,HCoV,HPIV,HMPV,HRV,HAdV,HBoV,和严重急性呼吸综合征冠状病毒2(SARS-CoV-2)通过实时PCR。SARS-CoV-2病毒在2019年至2022年间极大地影响了儿童和青少年急性呼吸道感染的病因。我们观察到在三个流行研究季节中主要呼吸道病毒的流行发生了巨大变化:HIFV,HRSV,和HPIV主要在2019-2020年发行;HMPV,HRV,和HCoV在2020-2021年占主导地位;和HRSV,SARS-CoV-2,HIFV,HRV是2021-2022年数量最多的代理商。有趣的是,在2020-2021年期间,HIFV的缺失和HRSV的显著减少,而HMPV不存在,在接下来的2021-2022年流行期间,HCoV显著下降。与其他两个流行季节相比,在2020-2021年期间检测到病毒共感染的频率明显更高。某些呼吸道病毒,HCoV,HPIV,HBoV,HRV,和HAdV,在合并感染中最常见。这项队列研究表明,在大流行前和大流行期间,在0-17岁的住院患者中,常见呼吸道病毒发生了剧烈的波动。每个研究时期最主要的病毒不同:2019-2020年的HIFV,2020-2021年的HMPV和2021-2022年的HRSV。发现SARS-CoV-2和HRV之间可能存在病毒-病毒相互作用,HRSV,HAdV,HMPV,和HPIV。仅在第三个流行季节(2022年1月至3月)才注意到COVID-19的发病率增加。
A wide range of human respiratory viruses are known that may cause acute respiratory infections (ARIs), such as influenza A and B viruses (HIFV), respiratory syncytial virus (HRSV), coronavirus (
HCoV), parainfluenza virus (HPIV), metapneumovirus (HMPV), rhinovirus (HRV), adenovirus (HAdV), bocavirus (HBoV), and others. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COronaVIrus Disease (COVID) that lead to pandemic in 2019 and significantly impacted on the circulation of ARIs. The aim of this study was to analyze the changes in the epidemic patterns of common respiratory viruses among children and adolescents hospitalized with ARIs in hospitals in Novosibirsk, Russia, from November 2019 to April 2022. During 2019 and 2022, nasal and throat swabs were taken from a total of 3190 hospitalized patients 0-17 years old for testing for HIFV, HRSV,
HCoV, HPIV, HMPV, HRV, HAdV, HBoV, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time PCR. The SARS-CoV-2 virus dramatically influenced the etiology of acute respiratory infections among children and adolescents between 2019 and 2022. We observed dramatic changes in the prevalence of major respiratory viruses over three epidemic research seasons: HIFV, HRSV, and HPIV mainly circulated in 2019-2020; HMPV, HRV, and
HCoV dominated in 2020-2021; and HRSV, SARS-CoV-2, HIFV, and HRV were the most numerous agents in 2021-2022. Interesting to note was the absence of HIFV and a significant reduction in HRSV during the 2020-2021 period, while HMPV was absent and there was a significant reduction of
HCoV during the following epidemic period in 2021-2022. Viral co-infection was significantly more frequently detected in the 2020-2021 period compared with the other two epidemic seasons. Certain respiratory viruses,
HCoV, HPIV, HBoV, HRV, and HAdV, were registered most often in co-infections. This cohort study has revealed that during the pre-pandemic and pandemic periods, there were dramatic fluctuations in common respiratory viruses registered among hospitalized patients 0-17 years old. The most dominant virus in each research period differed: HIFV in 2019-2020, HMPV in 2020-2021, and HRSV in 2021-2022. Virus-virus interaction was found to be possible between SARS-CoV-2 and HRV, HRSV, HAdV, HMPV, and HPIV. An increase in the incidence of COVID-19 was noted only during the third epidemic season (January to March 2022).