使用 CRISPR 增强用于治疗应用的 T 细胞效应子功能。
关键词: AP-1, activator protein 1 ARE, AU-rich element ARE-Del, deletion of the 3′UTR AREs from the Ifng/IFNG gene CAR T cells CAR, Chimeric Antigen Receptor CRISPR CRISPR, Clustered Regularly Interspaced Short Palindromic Repeat CRS, cytokine release syndrome CTLA-4, cytotoxic T-lymphocyte-associated protein 4 Cas, CRISPR-associated Cas9 Cytokines DGK, Diacylglycerol kinase DHX37, DEAH-box helicase 37 EBV, Epstein Barr virus FOXP3, Forkhead box P3 GATA, GATA binding protein Genome editing IFN, interferon IL, interleukin LAG-3, Lymphocyte Activating 3 NF-κB, nuclear factor of activated B cells PD-1, Programmed cell Death 1 PD-L1, Programmed Death Ligand 1 PTPN2, Protein Tyrosine Phosphatase Non-Receptor 2 Pdia3, Protein Disulfide Isomerase Family A Member 3 RBP, RNA-binding protein RNP, ribonuclear protein T cell effector function T cells TCR, T cell receptor TGF, transforming growth factor TIL, Tumor Infiltrating Lymphocyte TLRs, Toll-like receptors TNF, tumor necrosis factor TRAC, TCR-α chain TRBC, TCR-β chain UTR, untranslated region tTCR, transgenic TCR
来 源:
DOI:10.1016/j.cytox.2020.100049
PDF(Sci-hub)
PDF(Pubmed)