关键词： ADAM, a disintegrin and metalloproteinases AGE, advanced glycation end products Angiogenesis Cancer Collagen DDR1, discoidin domain receptor 1 ECM, extracellular matrix EGF, epidermal growth factor EGFR, epidermal growth factor receptor EMILIN1, elastin microfibril interfacer 1 EMILIN2, elastin microfibril interfacer 2 EMT, epithelial-mesenchymal transition ERα, estrogen receptor α ERβ, estrogen receptor β GBM, glioblastoma HA, hyaluronan HAS2, hyaluronan synthase 2 HAS2-AS1, HAS2 antisense 1 HB-EGF, heparin binding EGF HMGA2, high-mobility group AT-Hook 2 IBC, inflammatory breast cancer IGF-IR, insulin growth factor I receptor IR-A, insulin receptor A LEKTI, lympho-epithelial Kazal-type inhibitor LOX, lysyl oxidases LTBP, latent TGFβ-binding proteins MAGP, microfibril-associated glycoproteins MET, mesenchymal-epithelial transition MMP, matrix metalloproteinases Methodologies OB, osteoblast OI, osteogenesis imperfecta PARs, protease activated receptors PG, proteoglycans PLL, poly-l-lysine Proteoglycans ROS, reactive oxygen species RTK, receptor tyrosine kinase SLRP, small leucine rich proteoglycans SSR, solar-simulated radiation TGFβ, transforming growth factor β TNT, tunneling nanotubes UVR, ultraviolet radiation VEGF, vascular endothelial growth factor miR, microRNA tPA, tissue-type plasminogen activator uPA, urokinase-type plasminogen activator

来  源：   DOI：10.1016/j.mbplus.2020.100038   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
The extracellular matrix is engaged in an ever-evolving and elegant ballet of dynamic reciprocity that directly and bi-directionally regulates cell behavior. Homeostatic and pathophysiological changes in cell-matrix signaling cascades manifest as complex matrix phenotypes. Indeed, the extracellular matrix can be implicated in virtually every known human disease, thus, making it the most critical and dynamic \"organ\" in the human body. The overall goal of this Special Issue is to provide an accurate and inclusive functional definition that addresses the inherent complexity of matrix phenotypes. This goal is summarily achieved via a corpus of expertly written articles, reviews and original research, focused at answering this question empirically and fundamentally via state-of-the-art methods and research strategies.
摘要：
细胞外基质参与了动态互惠的不断发展和优雅的芭蕾舞，直接和双向地调节细胞行为。细胞-基质信号级联的稳态和病理生理变化表现为复杂的基质表型。的确,细胞外基质可以与几乎所有已知的人类疾病有关，因此，使其成为人体中最关键和最有活力的“器官”。本特刊的总体目标是提供一个准确和包容的功能定义，解决基质表型的固有复杂性。这个目标是通过一系列熟练的文章来实现的，评论和原创性研究，专注于通过最先进的方法和研究策略从经验和根本上回答这个问题。
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