关键词： Delayed recanalization Stroke penumbra perfusion tPA

Mesh ： Brain / blood supply diagnostic imaging physiopathology Cerebral Blood Volume / physiology Cerebrovascular Circulation / physiology Child Combined Modality Therapy / methods Diffusion Magnetic Resonance Imaging / methods statistics & numerical data Female Fibrinolytic Agents / therapeutic use Humans Ischemic Stroke / diagnosis physiopathology surgery Magnetic Resonance Angiography / methods statistics & numerical data Male Mechanical Thrombolysis / methods Middle Aged Reperfusion / adverse effects methods Risk Factors Thrombolytic Therapy / methods Time Factors Time-to-Treatment / standards trends Tissue Plasminogen Activator / therapeutic use Tomography, X-Ray Computed / methods Treatment Outcome

来  源：   DOI：10.1177/0271678X20978861   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
While the time window for reperfusion after ischemic stroke continues to increase, many patients are not candidates for reperfusion under current guidelines that allow for reperfusion within 24 h after last known well time; however, many case studies report favorable outcomes beyond 24 h after symptom onset for both spontaneous and medically induced recanalization. Furthermore, modern imaging allows for identification of penumbra at extended time points, and reperfusion risk factors and complications are becoming better understood. Taken together, continued urgency exists to better understand the pathophysiologic mechanisms and ideal setting of delayed recanalization beyond 24 h after onset of ischemia.
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