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Abstract：
BACKGROUND: Amyloid beta (Aβ) pathology is an Alzheimer\'s disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals.
METHODS: A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status.
RESULTS: Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003).
CONCLUSIONS: Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.
METHODS: A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status.
RESULTS: Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003).
CONCLUSIONS: Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.
摘要：
背景：淀粉样蛋白β（Aβ）病理是阿尔茨海默病的早期标志。在这里，我们评估了认知能力下降的纵向自我和信息报告的价值，以预测认知未受损的中年人的Aβ正电子发射断层扫描（PET）结果。
方法：来自ALFA+研究的261名参与者同时接受了[18F]氟美他莫PET和主观认知下降问卷（SCD-Q），扫描前3年。我们使用逻辑回归来评估SCD-Q评分（自我和线人）预测AβPET视觉读数的能力，和重复的方差分析，以评估SCD-Q评分的变化是否与Aβ状态有关。
结果：记忆力下降的自我感知（优势比[OR]=1.2），和线人对高管衰退的感知(OR=1.6)，增加了阳性扫描的概率。信息报告在扫描前3年预测AβPET结果。自我报告的高管下降的纵向增加是女性Aβ的预测因素（P=0.003）。
结论：认知能力下降的主观报告有助于预测Aβ，并可能改善招募策略。
方法：来自ALFA+研究的261名参与者同时接受了[18F]氟美他莫PET和主观认知下降问卷（SCD-Q），扫描前3年。我们使用逻辑回归来评估SCD-Q评分（自我和线人）预测AβPET视觉读数的能力，和重复的方差分析，以评估SCD-Q评分的变化是否与Aβ状态有关。
结果：记忆力下降的自我感知（优势比[OR]=1.2），和线人对高管衰退的感知(OR=1.6)，增加了阳性扫描的概率。信息报告在扫描前3年预测AβPET结果。自我报告的高管下降的纵向增加是女性Aβ的预测因素（P=0.003）。
结论：认知能力下降的主观报告有助于预测Aβ，并可能改善招募策略。
