{Reference Type}: Journal Article
{Title}: Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4.
{Author}: Sánchez-Benavides G;Salvadó G;Arenaza-Urquijo EM;Grau-Rivera O;Suárez-Calvet M;Milà-Alomà M;González-de-Echávarri JM;Minguillon C;Crous-Bou M;Niñerola-Baizán A;Perissinotti A;Gispert JD;Molinuevo JL; ;
{Journal}: Alzheimers Dement (Amst)
{Volume}: 12
{Issue}: 1
{Year}: 2020
暂无{DOI}: 10.1002/dad2.12127
{Abstract}: <B>BACKGROUND: </B>Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals.<BR><B>METHODS: </B>A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status.<BR><B>RESULTS: </B>Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003).<BR><B>CONCLUSIONS: </B>Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.