%0 Journal Article
%T Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4.
%A Sánchez-Benavides G
%A Salvadó G
%A Arenaza-Urquijo EM
%A Grau-Rivera O
%A Suárez-Calvet M
%A Milà-Alomà M
%A González-de-Echávarri JM
%A Minguillon C
%A Crous-Bou M
%A Niñerola-Baizán A
%A Perissinotti A
%A Gispert JD
%A Molinuevo JL
%A  
%J Alzheimers Dement (Amst)
%V 12
%N 1
%D 2020
%M 33204815
暂无%R 10.1002/dad2.12127
%X <B>BACKGROUND: </B>Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals.<BR><B>METHODS: </B>A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status.<BR><B>RESULTS: </B>Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003).<BR><B>CONCLUSIONS: </B>Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.