关键词: ALT, alanine transaminase AST, aspartate transaminase AUC, area under the curve BUN, blood urea nitrogen CHO, cholesterol CO2, carbon dioxide CR, creatinine Combination therapy Cu2+, copper ions DL, drug loading DLS, dynamic light scattering DMSO, dimethyl sulfoxide DNA, deoxyribonucleic acid DOX, doxorubicin DSPE-PEG2000, 2-distearoyl-snglycero-3-phosphoethanolamine-N-[methyl(polyethylene glycol)-2000 DTT, d,l-dithiothreitol EDTA, ethylene diamine tetraacetic acid EE, encapsulation efficacy FBS, fetal bovine serum GSH, glutathione H&E, hematoxylin and eosin H2O2, hydrogen peroxide HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid HPLC, high-performance liquid chromatography HSPC, hydrogenated soybean phospholipids IC50, half maximal inhibitory concentration IVIS, in vivo imaging system MLVs, multilamellar vesicles MRT, mean residence time MTD, maximum tolerated dose MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Nanoparticles PBS, phosphate buffer saline PDI, polydispersity index PSD LPs, PTX-S-DOX liposomes PSD NPs, PTX-S-DOX self-assembled nanoparticles PSD, PTX-S-DOX PTX, paclitaxel Paclitaxel–doxorubicin prodrug Prodrug ROS, reactive oxygen species Remote loading liposomes SD, standard deviation Safety TEM, transmission electron microscopy UV, ultraviolet
来 源:
DOI:10.1016/j.apsb.2020.04.011
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