UNASSIGNED:使用非接触式声学微攻丝光学相干弹性成像(AμT-OCE)评估用紫外线交联(CXL)治疗的离体人角膜的各向异性弹性特性的变化。
UNASSIGNED:在离体实验室研究中,对正常和CXL人供体角膜进行了声学微拍打OCE。
未经证实:正常人供体角膜(n=22)分为4个亚组。所有样品都储存在optisol中。
UNASSIGNED:弹性属性(平面内Young\'s,E,和飞机外,G,使用非接触式AμT-OCE定量正常和紫外线CXL处理的人角膜的剪切模量)。使用几乎不可压缩的横向各向同性模型从AμT-OCE数据重建模量。独立地,角膜弹性模量也通过破坏性力学测试(拉伸引伸计和剪切流变计)进行测量。
未经评估:角膜弹性模量(面内杨氏模量,E,在飞机上,μ,和飞机外,G,剪切模量)可以在正常和CXL处理的组织中进行评估,以及在CXL过程中使用非接触式AμT-OCE进行监测。
UNASSIGNED:交联诱导人角膜平面内和平面外弹性模量的显著增加。配对研究中的统计平均值(手术前和手术后,n=7)的面内杨氏模量,E=3μ,从19兆帕增加到43兆帕,而面外剪切模量,G,从188kPa增加到673kPa。在单独的亚组中进行的机械测试支持CXL诱导的角膜模量变化,并且通常与非接触式AμT-OCE测量结果一致。
UNASSIGNED:人类角膜是一种高度各向异性的材料,其中平面内的机械性能与平面外的机械性能非常不同。非接触式AμT-OCE可以测量紫外线CXL导致的人体角膜各向异性弹性特性的变化。
UNASSIGNED: To evaluate changes in the anisotropic elastic properties of ex vivo human cornea treated with ultraviolet cross-linking (CXL) using noncontact acoustic micro-tapping optical coherence elastography (AμT-OCE).
UNASSIGNED: Acoustic micro-tapping OCE was performed on normal and CXL human donor cornea in an ex vivo laboratory study.
UNASSIGNED: Normal human donor cornea (n = 22) divided into 4 subgroups. All samples were stored in optisol.
UNASSIGNED: Elastic properties (in-plane Young\'s, E, and out-of-plane, G, shear modulus) of normal and ultraviolet CXL-treated human corneas were quantified using noncontact AμT-OCE. A nearly incompressible transverse isotropic model was used to reconstruct moduli from AμT-OCE data. Independently, cornea elastic moduli were also measured with destructive mechanical tests (tensile extensometry and shear rheometry).
UNASSIGNED: Corneal elastic moduli (in-plane Young\'s modulus, E, in-plane, μ, and out-of-plane, G, shear moduli) can be evaluated in both normal and CXL treated tissues, as well as monitored during the CXL procedure using noncontact AμT-OCE.
UNASSIGNED: Cross-linking induced a significant increase in both in-plane and out-of-plane elastic moduli in human cornea. The statistical mean in the paired study (presurgery and postsurgery, n = 7) of the in-plane Young\'s modulus, E = 3 μ , increased from 19 MPa to 43 MPa, while the out-of-plane shear modulus, G, increased from 188 kPa to 673 kPa. Mechanical tests in a separate subgroup support CXL-induced cornea moduli changes and generally agree with noncontact AμT-OCE measurements.
UNASSIGNED: The human cornea is a highly anisotropic material where in-plane mechanical properties are very different from those out-of-plane. Noncontact AμT-OCE can measure changes in the anisotropic elastic properties in human cornea as a result of ultraviolet CXL.